不完全川崎病患儿血浆D-二聚体的表达及与冠状动脉病变关系探讨  

Probing Expression of D-Dimer in Untypical Kawasaki Diease and Relationship with Coronary Artery Diease

作　　者：孙春蕾[1] 刘晓东[2] 秦富香[2] 张爱平[2] 姜娜娜[3] 

机构地区：[1]潍坊医学院儿科学教研室,山东潍坊261053 [2]潍坊医学院附属潍坊市人民医院儿内科 [3]潍坊医学院附属潍坊市人民医院医疗部

出　　处：《潍坊医学院学报》2011年第6期417-419,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 通过检测不完全川崎病（KD）患儿血浆D-二聚体变化,探讨不完全KD早期诊断手段及与冠状动脉病变（CAD）的关系.方法 应用乳胶凝集法（Latex法）检测不完全KD组（n=20）治疗前后血浆D-二聚体水平并与对照组（n=30）儿童比较.结果 不完全KD组血浆D-二聚体明显高于健康对照组,差异有统计学意义（P＜0.05）.不完全KD组治疗2周后D-二聚体水平低于治疗前（P＜0.05）.CAD组血浆D-二聚体水平治疗前、后均高于无冠状动脉病变（NCAD）组（P＜0.05）.结论 D-二聚体在不完全KD急性期即升高,可协助早期诊断；D-二聚体对不完全KD患儿CAD发生的预测有一定的指导作用.Objective To approach the early diagnosis method of untypical Kawasaki Diease （ KD ） and it＇s relationship with coronary artery diease （ CAD） by detecting the changes of plasma D-dimer lever in KD children. Methods The levels of plasma D-dimer was measured by latex agglutination among 20 KD patients and 30 healthy children. Results The level of plasma D-dimer was significantly higher than that in the healthy group I P 〈 0.05 ）. The level of plasma D-dimer steped down after treated 2 weeks （ P 〈 0. 05 ）. Plasma D-dimer in group CAD was significantly higher than that in the group NCAD （ P 〈0. 05 ）. Conclusion D-dimer is step-up in acute phase of KD, it can assist early diagnosis and may be a sensitive predictor of coronary artery disease.

关 键 词：不完全川崎病 D-二聚体 临床意义 儿童 

分 类 号：R725.9[医药卫生—儿科]