抗突变型瓜氨酸波形蛋白抗体在幼年特发性关节炎中的诊断意义  

Diagnostic Value of Anti-mutated Citrullinated Vimentin Antibody in Juvenile Idiopathic Arthritis

作　　者：刘润荣[1] 王晓东[1] 马秀芬[1] 王炎强[1] 孙希志[1] 

机构地区：[1]潍坊医学院附属医院风湿科,山东潍坊261031

出　　处：《潍坊医学院学报》2011年第6期465-467,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 通过检测幼年特发性关节炎（JIA）患者血清中的抗突变型瓜氨酸波形蛋白（MCV）抗体,探讨其在JIA诊断方面的应用价值.方法 采用ELISA法检测87例JIA患者,55例非JIA对照,30例成人RA患者血清中的抗MCV抗体,进行组间比较.结果 JIA组患者中,抗MCV抗体的敏感性和特异性分别为44.8％和98.2％,与非JIA对照组比较差异有统计学意义（P＜0.01）,其中多关节型及少关节型与非JIA对照组比较差异亦有统计学意义（P＜0.01）.在JIA组患者中抗MCV抗体、抗CCP抗体、RF和AKA的敏感性分别为44.8％,35.6％,14.9％和10.3％,抗MCV抗体的敏感性明显高于RF和AKA,差异有统计学意义（P＜0.05）.结论 抗MCV抗体在JIA患者中的敏感性虽不及成人RA,但对JIA的诊断仍具有较高的敏感性和特异性,特别是对多关节型和少关节型JIA的诊断更有价值.Objective To detect anti-mutated citrullinated vimentin（MCV） antibody in patients with juven- ile idiopathic arthritis （ JIA）, to evaluate the diagnostic value of serum anti-MCV antibodv in JIA. Methods Anti-MCV antibody was detected by ELISA in the sera of 87 JIA patients,55 other rheumatic diseases and healthy children and 30 adults RA patients and the results were compared statistically. Results Anti-MCV antibody had a sensitivity of 44.8% and a specificity of 98.2% in JIA. The positive rate of Anti-MCV antibody was significantly higher in JIA patients than that in control groups（ P 〈 0. 01 ） , so did polyarticular and oligoarticular subtype compared with control children. The sensitivitv of anti-MCV,anti-CCP, RF and AKA were 44.8% ,35.6%, 14.9% and 10.3% in JIA, anti-MCV was more sensitivitv than RF and AKA （ P 〈 0.05 ）. Conclusion It suggestes that the detection of anti-MCV is useful for the diagnosis of JIA. Anti -MCV shows relatively more valuable in polyarticular and oligoarticular subtype JIA

关 键 词：幼年特发性关节炎 抗突变型瓜氨酸波形蛋白抗体 诊断 

分 类 号：R593[医药卫生—内科学]