硅胶控释型丁酸对断奶仔猪生长性能和肠黏膜屏障的影响  

Silica Gel Controlled-Release Butyrate Affects Growth Performance and Intestinal Mucosal Barrier in Weaned Piglets

作　　者：胡彩虹[1] 朱康 钱仲仓[1] 栾兆双[1] 李卫芬[1] 

机构地区：[1]浙江大学动物科学学院饲料科学研究所,杭州310058

出　　处：《动物营养学报》2011年第12期2170-2176,共7页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金(31072039);浙江省自然科学基金(Z3100071);农业部“948”项目(2011-G7-1)

摘　　要：本试验以硅胶为控释载体,制备和表征了硅胶控释型丁酸(SG-B),并以丁酸钠为对照,旨在研究SG-B对断奶仔猪生长性能和肠黏膜屏障的影响。选用平均体重为(5.8±0.2)kg的54头21日龄"杜×长×大"断奶仔猪,按胎次一致、体重相近的原则随机分为3组:1)对照组,饲喂基础饲粮;2)丁酸钠组,饲喂基础饲粮+0.10%丁酸钠(丁酸含量为0.078%);3)SG-B组,饲喂基础饲粮+0.19%SG-B(丁酸含量为0.078%),每组3个重复,每个重复6头仔猪,公母各占1/2。试验期10 d。结果表明:1)采用室温过量浸渍法制备和表征SG-B,热重分析表明丁酸负载量为41.1%;2)和对照组相比,SG-B组显著提高了断奶仔猪的平均日增重(P<0.05),显著降低了料重比和腹泻率(P<0.05);3)SG-B组血浆D-乳酸浓度和二胺氧化酶活性显著低于对照组(P<0.05),和丁酸钠组相比,差异不显著(P>0.05);4)SG-B组十二指肠、空肠、回肠绒毛高度和绒毛高度与隐窝深度比值显著高于对照组(P<0.05),十二指肠和回肠隐窝深度显著低于对照组(P<0.05)。结果提示,饲粮中添加0.19%SG-B能降低断奶仔猪腹泻率,提高生长性能,保护肠黏膜屏障。This experiment was conducted to study the effects of silica gel controlled-release butyrate（SG-B） on growth performance and intestinal mucosal barrier in weaned piglets.SG-B was synthesized and characterized.A total of 54 piglets（Duroc × Landrace × Yorkshire） with an average body weight of（5.8±0.2） kg were weaned at 21 d,and randomly allocated into 3 groups： control group（basal diet）,sodium butyrate group（basal diet ＋ 0.10% sodium butyrate）,and SG-B group（basal diet ＋ 0.19% SG-B）,with 3 replicates in each group and 6 piglets per replicate.The experiment lasted for 10 days.The results showed as follows： 1） the butyrate content was 41.1% in the SG-B.2） The average daily gain of the SG-B group was significantly higher than that of the control group（P0.05）,and the feed/gain and diarrhea rate of the SG-B group were significantly lower than those of the control group（P0.05）.3） D-lactate concentration and diamine oxidase activity in plasma of the SG-B group were significantly lower than those of the control group（P0.05）,and there was no significant difference between the SG-B group and sodium butyrate group（P0.05）.4） The villus height and villus height/crypt depth in the duodenum,jejunum,and ileum of the SG-B group were significantly higher than those of the control group（P0.05）,and the crypt depth in the duodenum and ileum was significantly lower than that of the control group（P0.05）.The results indicate that supplementation with 0.19% SG-B can improve growth performance,decrease diarrhea rate and protect intestinal mucosal barrier.

关 键 词：硅胶控释型丁酸 断奶仔猪 生长性能 肠黏膜屏障 

分 类 号：S828[农业科学—畜牧学]