恩诺沙星微囊在猪体内的药物动力学  

Pharmacokinetics of Enrofloxacin Microcapsules in Pigs

作　　者：赵瑞娇[1] 胡亚南[1] 张凤凤[1] 严元宠 赵建乐[1] 薛鹏浩[1] 孔蓓[1] 卢怡竹[1] 李引乾[1] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨陵712100 [2]陕西安邦德生物科技有限公司,西安710075

出　　处：《西北农业学报》2011年第12期11-15,共5页Acta Agriculturae Boreali-occidentalis Sinica

基　　金：西北农林科技大学大学生创新基金资助项目

摘　　要：为了给兽医临床合理用药提供依据,分析恩诺沙星微囊(Enrofloxacin Microcapsules,EM)和恩诺沙星原粉(Enrofloxacin,ENR)在猪体内的药物代谢动力学过程。猪单剂量分别灌服EM和ENR30mg.kg-1,72h内16次前腔静脉采血,高效液相色谱法(HPLC)测定猪血浆中ENR的质量浓度。结果表明,6头猪灌服EM和ENR后,其药动学配置均符合有吸收因素二室药代动力学模型。最佳药时曲线方程为ρ(EM)=11.326 3e-0.353 8t+5.420 6e-0.066 1t-16.746 9e-0.979 8t和ρ(ENR)=11.251 1e-0.934 7t+5.330 1e-0.079 9t-16.581 2e-2.965 7t。恩诺沙星微囊在猪体内的吸收相半衰期(t1/2ka)为(0.769 5±0.250 9)h,分布相半衰期(t1/2a)为(2.160 3±0.704 1)h,消除相半衰期(t1/2β)为(10.522 4±0.719 5)h,药时曲线下面积(AUC)为(92.924 3±5.308 4)mg.L-1.h。说明恩诺沙星微囊在猪体内吸收迅速,消除相对较慢。Pharmacokinetic parameters of Enrofloxacin Microcapsules（EM） and Enrofloxacin（ENR） in pig were calculated.Six pigs were treated with a single dosage of ENR（30 mg·kg-1） orally,while the blood samples were collected from precaval vein within 72 hours after giving drug.The concentrations of ENR in serum were determined by high performance liquid chromatography（HPLC）.The results showed that the two-compartment open model with first-order absorption factor adequately described concentrations of EM and ENR in serum disposition and best concentration-time equations were ρ（EM）=11.326 3e-0.353 8t＋5.420 6e-0.066 1t-16.746 9e-0.979 8t and ρ（ENR）=11.251 1e-0.934 7t＋5.330 1e-0.079 9t-16.581 2e-2.965 7t.The primary pharmacokinetic parameters of EM were t1/2ka=（0.769 5±0.250 9） h,t1/2a=（2.160 3±0.704 1） h,t1/2β=（10.522 4±0.719 5） h,and AUC=（92.924 3±5.308 4） mg·L-1·h.Which indicated that EM was completely absorbed with a slowly absorption rate,but eliminated slowly in the blood after single oral administration.

关 键 词：恩诺沙星微囊 猪 药动学 高效液相色谱法 

分 类 号：S859.7[农业科学—临床兽医学]