高海拔地区睡眠呼吸暂停低通气综合征相关发病因素探讨  

Relationship between Features and Risk Factors of Sleep Apnea Hypoxic Syndrome at High Altitude

作　　者：郝丽娟[1] 任雨青[1] 马佐鹏[1] 庞怀霞[1] 

机构地区：[1]青海红十字医院耳鼻咽喉科睡眠室,810000

出　　处：《高原医学杂志》2011年第4期10-13,共4页Journal of High Altitude Medicine

基　　金：青海科技厅重点攻关项目;项目编号2008-N-139

摘　　要：目的:了解高海拔地区睡眠呼吸暂停低通气综合征患者(sleep apnea-hypopnea syn-drome,SAHS)临床发病特点及探讨相关危险因素。方法:分析2007年1月—2009年12月在我院就诊疑似SAHS患者979例的一般资料及夜间多导睡眠监测(PSG)指标。结果:①经PSG监测分析后确诊的SAHS成年患者890例,未确诊者89例;②男性SAHS患者40岁～组比重最高,女性50岁～组所占比例最高,男女之比达6.671;③随着病情加重夜间指端最低氧饱和度、睡眠中平均指氧饱和度逐渐降低;夜间血压逐渐上升;④随着病情加重夜间睡眠中微觉醒次数与累计缺氧时间明显增加;⑤颈围、体质指数、收缩压、缺氧时间与呼吸暂停关系最为密切。结论:高海拔地区PSG监测仍为诊断SAHS的金指标;肥胖、年龄、粗颈围是SAHS发病的高危因素,对于高发年龄段的肥胖、粗颈、高血压患者应高度怀疑SAHS,建议行PSG监测。而对于确诊的SAHS患者,除睡眠呼吸紊乱指数(AHI)的诊断指标外,夜间指端最低氧饱和度、累计缺氧时间也可在一定程度上说明病情的严重程度。objective：To deal with features and risk factors of obstructive sleep apnea hypoxic syndrome（SAHS） at high altitude.Methods：Materials of 979 patients with suspecting SAHS from Jan 2007 to Dec 2009 were reviewed retrospectively with medical records and overnight polysomnographic indices.Results：①890 of 979 cases had the SAHS,and 89 cases were not diagnosed to have SAHS;②40-year-old male patients and 50-year-old female patients had the highest proportion of SAHS,male versus female in a ratio of 6.671;③the little awakening times and accumulative hypoxic time increased with serious illness;④apnea related with closely neck circumference,body mass index and systolic pressure.Conclusions：Fatty and crude neck are risk factors of SAHS,and when the fatty,crude neck and hypertension patients would be suspected to have SAHS,it is important that PSG is performed.In SAHS patients,increasing serious illness will be foreboded with apnea and hypopnea index（AHI）,night oxygen saturation and accumulated hypoxic time.

关 键 词：高海拔 睡眠呼吸暂停低通气综合征 多导睡眠监测 

分 类 号：R766[医药卫生—耳鼻咽喉科]