民航非酒精性脂肪肝飞行员血清瘦素、血糖和血脂变化的研究  

The study on serum leptin, blood lipid and blood glucose in nonalcoholic fatty liver disease among civilaviation pilots

作　　者：王妍[1] 熊浩伟 李婷[3] 周毓瑾[1] 

机构地区：[1]中国民用航空局民用航空医学中心,北京100123 [2]民航广州医院,广州510406 [3]中国南方航空股份有限公司,广州510406

出　　处：《中华航空航天医学杂志》2011年第4期270-273,共4页Chinese Journal of Aerospace Medicine

摘　　要：目的分析2009年4月至2010年7月在民航广州医院航空体检中心体检的民航60例现役非酒精性脂肪肝（nonalcoholic fatty liver disease, NAFLD）飞行员血清瘦素、血糖、血脂的变化，探讨飞行员患NAFLD的危险因素及其预防措施。方法60例NAFLD飞行员作为试验组，体检结论正常的60例飞行员作为对照组。询问病史，空腹测量身高、体重、腰围、臀围及血压；检测血脂、空腹血糖（fasting plasma glucose，FPG）和血清瘦素水平，并进行组间比较。结果NAFLD组体重指数（bodymass index，BMI）、腰臀比、收缩压、舒张压、甘油三酯（triglyceride，TG）和血清瘦素水平较对照组显著上升（t=4．62-12．20，P〈0．01）；FPG较对照组上升（t=2．63，P〈0．05）；高密度脂蛋白胆固醇（highdensitylipid—cholesterol，HDL-C）明显下降（t=3．65，P〈0．01）。瘦素水平与TG、FPG呈正相关（r=0．72、0．82，P〈0．05），与HDL-C呈负相关（r=-0．62，P〈0．05）。结论飞行员患NAFLD与其饮食结构及活动减少造成肥胖有关，并与瘦素水平升高密切关联。应加强对患NAFLD飞行员的预防和治疗工作，为飞行员的健康和飞行安全提供保障。Objective To investigate the changes of serum leptin, blood glucose and blood lipid of the civil pilot with nonalcoholic fatty liver disease （NAFLD） and to discuss the risk factors of NAFLD and related prevention measures. Method Sixty pilots with NAFLD and 60 normal pilots were respectively selected as NAFLD and control group. Their body mass index （BMI）, waist-to-hip ratio （WHR）, blood pressure, blood lipid, fasting plasma glucose （FPG）, triglyceride （TG）, highdensity lipid-cholesterol （HDL-C） and serum leptin were tested and compared. Result The BMI, WHR, systolic/diastolic blood pressure, TG and serum leptin in NAFLD group were significantly higher than those in normal control group （t= 4. 62-12. 20 , P〈0.01）, FPG was higher than that in normal control group （t= 2.63, P〈0.05）, the HDL-C in NAFLD group was significantly lower than that in normal control group （t= 3.65, P〈0. 01）. Serum leptin was positively correlated with TG and FPG （r=0.72, 0.82, P〈0.05） and serum leptin was negatively correlated with HDL-C （r=-0.62, P〈0.05）. Conclusions Pilotls NAFLD is related with the obesity caused by unhealthy diet and less exercise and closely related with high level of leptin. More attention should be paid on prevention and treatment of the pilots with NAFLD so to ensure the health of pilots and flight safety.

关 键 词：瘦素 脂肪肝 血糖 胆固醇 甘油三酯类 脂蛋白类 HDL 

分 类 号：R85[医药卫生—航空、航天与航海医学]