高龄急性心肌梗死溶栓失败联用替罗非班26例分析  

Clinical Effect of Tirofiban Hydrochloride Combination Urokinase Thrombolysis for 26 Elder Patients Suffered Acute Myocardial Infarction

作　　者：梁发杰 刘新宏[2] 王军奎[2] 

机构地区：[1]陕西省铜川市第二人民医院内科,铜川727007 [2]陕西省人民医院心内科,西安710072

出　　处：《中国医药导刊》2011年第11期1894-1895,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察高龄(≥75岁)急性ST段抬高心肌梗死(STEMI)患者尿激酶溶栓治疗失败患者联用替罗非班的疗效及安全性。方法:26例高龄急性STEMI患者给予中剂量(100万U)的尿激酶溶栓治疗后3小时,症状不能缓解或恶化者,予以1/2剂量替罗非班抗栓治疗。并在住院10日内行冠脉造影,观察其临床治疗有效率、TIMI血流分级、心源性死亡等不良事件发生率及出血反应。结果:高龄溶栓失败联用替罗非班的患者临床有效率82.6%,TIMI血流3级发生率56.6%,无心源性死亡,溶栓联用替罗非班者出血率为15.6%,但无脑出血及重度出血发生。结论:高龄急性STEMI患者中剂量尿激酶溶栓失败患者联用替罗非班可提高再通率、改善微血管灌注,安全有效。Objecrive：To observe the clinical effect and safety of Tirofiban Hydrochloride for patients aging over 75 years old suffered STEMI and received a failed urokinase thrombolysis treatment Methods：Half dose Tirofiban Hydrochloride was injected to 26 cases of STEMI who received 1 million unit urokinase for thrombolysis in myocardial infarction but the symptoms did not relieve three hours later.The clinical effectiveness,TIMI blood current grade,probability of cardiac death or bleeding were evaluated by Coronary angiography（CAG） in ten days.Resnlts：CAG showed that the rates of the clinical effectiveness 82.6%,TIMI 3 grade 56.6%,bleeding 15.6%,no cardiac death and brain hemorrhage or other severe bleeding events.Conclusion：Tirofiban Hydrochloride combination urokinase thrombolysis for elder STEMI provides better clinical effct.

关 键 词：高龄 急性心肌梗死 溶栓失败 替罗非班 

分 类 号：R542.22[医药卫生—心血管疾病]