地尔硫联合曲美他嗪治疗不稳定型心绞痛的临床研究  

The Clinical Study on the Combination Treatment of Diltiazem and Trimetazidinefor Unstable Angina Pectoris

作　　者：李景隆[1] 叶国鸿[1] 白健雄 陈春林[1] 

机构地区：[1]广东省肇庆市第二人民医院心血管中心,肇庆526060

出　　处：《中国医药导刊》2011年第11期1927-1928,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨地尔硫联合曲美他嗪治疗不稳定型心绞痛的临床疗效。方法:将116例不稳定型心绞痛患者随机分为观察组和对照组各58例。对照组予以曲美他嗪60mg/d,分3次口服;观察组在对照组治疗基础上加用地尔硫(?)注射液。结果:观察组能够显著能够减少心绞痛发作频次,并使心电图上心肌缺血范围和程度减轻,观察组明显优下对照组(P<0 05,或P<0 01),观察组总有效率86.21%,优于对照组70.69%(P<0.05);且两药联合后,患者血流动力学及血脂水平下降更明显,两组比较,差异均有统计学意义(P<0.05或,P<0.01)。结论:地尔硫联合曲美他嗪治疗治疗能更好地改善不稳定型心绞痛患者血流动力学、血脂状况,改善微循环值得推广使用。Objective：To explore the clinical effectiveness of the combination between diltiazem and trimetazidine on unstable angina pectoris.Methods：116 cases with unstable angina pectoris were randomly separated into two groups including observation group and control group,each of which had 58 cases.ln control group,the patients received oral administration of trimetazidine with the dose of 60mg/d,which was separated into three times in all.Except for this,the patients also received diltiazem in observation group.Results：The frequency of angina pectoris attacks significantly reduced and the sphere and degree of heart muscle ischemia lessened in observation group compared with control group（P0.05 or P0.01）.The total effective rates were 86.21%in observation group and 70.69%in control group respectively（P0.05）.Furthermore,the combination treatment of two drugs can obviously reduce the level of lipids and improve hemodynamics in patients.There was statistical significance between two groups（P0.05 or P0.01） Conclusion：The therapeutic alliance of diltiazem and trimetazidine can preferably improve the hemodynamics,the level of lipids,microcirculation in patients with unstable angina pectoris and it deserves to be generalized.

关 键 词：心绞痛 地尔硫 曲美他嗪 

分 类 号：R541.4[医药卫生—心血管疾病]