Sensing of chlorpheniramine in pharmaceutical applications by sequential injector coupled with potentiometer  

作　　者：Tawfik A.Saleh 

机构地区：[1]Chemistry Department,King Fahd University of Petroleum and Minerals,P.O.Box 6724,Dhahran 31261,Saudi Arabia

出　　处：《Journal of Pharmaceutical Analysis》2011年第4期246-250,共5页药物分析学报（英文版）

摘　　要：This paper reports on development of a system consisting of a portable sequential injector coupled with potentiometric unit for sensing of chlorpheniramine （CPA）, based on the reaction of CPA with potassium permanganate in acidic media. Various experimental conditions affecting the potential intensity were studied and incorporated into the procedure. Under the optimum conditions, linear relationship between the CPA concentration and peak area was obtained for the concentration range of 0.1-50 ppm. The method reflects good recovery with relative standard deviation （RSD）〈 3 %. The detection limit was 0.05 ppm. The developed method was successfully applied for determination of CPA in pure form and in pharmaceutical dosage forms. The results, obtained using the method, are in accord with the results of the British pharmacopoeia method. In addition to its accuracy and precision, the method has the advantages of being simple, inexpensive and rapid.This paper reports on development of a system consisting of a portable sequential injector coupled with potentiometric unit for sensing of chlorpheniramine （CPA）, based on the reaction of CPA with potassium permanganate in acidic media. Various experimental conditions affecting the potential intensity were studied and incorporated into the procedure. Under the optimum conditions, linear relationship between the CPA concentration and peak area was obtained for the concentration range of 0.1-50 ppm. The method reflects good recovery with relative standard deviation （RSD）〈 3 %. The detection limit was 0.05 ppm. The developed method was successfully applied for determination of CPA in pure form and in pharmaceutical dosage forms. The results, obtained using the method, are in accord with the results of the British pharmacopoeia method. In addition to its accuracy and precision, the method has the advantages of being simple, inexpensive and rapid.

关 键 词：SENSING Flow injection ChlorpheniraminePotentiometry 

分 类 号：R927.2[医药卫生—药学]