类风湿性关节炎联合用药的研究  

Study of rheumatoid arthritis combination therapy

作　　者：庞泽文[1] 

机构地区：[1]广东省湛江中心人民医院,广东湛江524037

出　　处：《中国当代医药》2012年第11期32-33,35,共3页China Modern Medicine

摘　　要：目的探讨联合用药治疗类风湿性关节炎。方法把36例患者任意分为甲乙两个小组,甲组18例患者接受甲氨喋呤与青霉胺联合用药的治疗方式,乙组18例患者则接受联合甲氨喋呤与羟氯喹的用药方式。结果甲乙两个小组患者在接受药物联合治疗之前各项指标之间不存在统计学上的差异,在接受药物联合治疗之后,每一项指标的值都得到了明显降低,P值小于0.05,差异有统计学意义。甲乙两个小组临床治疗效果有效的例数均是17例,占小组总人数的94.44%;无效只有1例,占小组总人数的5.56%。两个小组临床治疗的综合评价并不存在统计学上的差异,其中P值大于0.05。甲组药物引发不良反应的概率及症状的严重程度都明显低于乙组。结论甲乙两个小组联合用药策略都可以获得令人满意的临床治疗效果,疗效的综合评价在整体上是一样的。联合用药治疗类风湿性关节炎的根本要求是结合具有差异作用机制的抗风湿药,在不同的时间段中预防组织与细胞受到伤害,实现获得协同或相加的临床疗效,而不良反应不重复。在临床上选择联合应用抗风湿药对类风湿性关节炎患者进行治疗,可以有效改善其症状,抑制骨质发生损坏,并控制病情的发展。Objective To explore the combined medication in treatment of rheumatoid arthritis.Methods Thirty six patients were arbitrarily divided into two groups,group A and B,18 patients of group A received methotrexate combined with penicillamine medication therapy,18 patients of group B received combined with methotrexate and hydroxychloroquine use way.Results Two groups＇ patients received combined drug therapy before each index does not exist between the statistical difference,in those receiving the drug combination therapy,each index values were significantly decreased,P value less than 0.05,there were significant statistical difference.The effective cases in two groups were 17 cases,accounting for 94.44% of the total number of invalid group;only 1 case,accounting for 5.56% of the total number of the group.A panel of two clinical therapeutic evaluation did not exist significant statistical difference,in which the P value was greater than 0.05.Drug induced adverse reactions：the probability and severity of symptoms were significantly lower than group B.Conclusion Two groups combination strategy can obtain satisfactory curative effect,the clinical evaluation on the whole is the same.Combined medication in treatment of rheumatoid arthritis of the fundamental requirement is combined with the difference mechanisms of action of antirheumatic drugs,during different time periods in the prevention of tissue and cell damage,to achieve synergistic or additive clinical effect and adverse reactions,without repetition.In the clinical choice of combined use of antirheumatic drugs for rheumatoid arthritis are treated,can effectively improve the symptoms,inhibit bone damage,and control disease development.

关 键 词：类风湿性关节炎 联合用药 甲氨喋呤 青霉胺 羟氯喹 分析 

分 类 号：R684.3[医药卫生—骨科学]