HPLC法测定安乃近片的含量  

Determination of Metamizole SodiumTablets by HPLC

作　　者：霍天凤 张延华[2] 

机构地区：[1]河南省焦作市食品药品检验所,河南焦作454000 [2]焦煤集团中央医院一分院,河南焦作454100

出　　处：《中国当代医药》2012年第11期53-54,共2页China Modern Medicine

摘　　要：目的建立HPLC法测定安乃近片的含量。方法采用KromasilC18柱(250.0mm×4.6mm,5μm),以磷酸盐缓冲液(pH为7.0)-甲醇(72:28)为流动相,UV检测波长254nm,流速1.0mL/min。结果安乃近在104.4～417.6μg/mL范围内呈良好的线性关系(r=0.9999),平均回收率为99.7%,RSD=0.64%。结论本法测定安乃近片的含量科学、准确、简便,可用于安乃近片的质量控制。Objective To establish an HPLC method for the determination of Metamizole SodiumTablets.Methods Metamizole Sodium was separated on Kromasil C18（250.0 mm×4.6 mm,5 μm） and detected at 254 nm,with phosphate buffer（pH was 7.0）-methanol（72：28） as mobile phase,the flow rate was 1.0 mL/min.Results Metamizole Sodium presented a good linear correlation within the range of（104.4-417.6） μg/mL（r = 0.999 9）.The average recovery was 99.7%,with RSD=0.64%.Conclusion This method is scientific,accurate and simple.This study provides the reference to establish quality standard for Metamizole Sodium Tablets.

关 键 词：安乃近片 含量 HPLC 测定 

分 类 号：R286.0[医药卫生—中药学]