CD4^+ T细胞内腺苷三磷酸检测技术在器官移植领域的应用进展  

Application of the immune function assay detecting CD4^+ T lymphocyte adenosine triphosphate level in organ transplantation

作　　者：王毓琳[1] 杨守国[1] 王春生[1] 

机构地区：[1]复旦大学附属中山医院心外科上海市心血管病研究所复旦大学器官移植中心,上海200032

出　　处：《中华移植杂志（电子版）》2011年第3期45-49,共5页Chinese Journal of Transplantation(Electronic Edition)

基　　金：2009年上海市人才发展基金;2010年上海市领军人才专项资金

摘　　要：科学监测器官移植受者免疫水平是进一步提供个体化免疫抑制治疗、提高受者长期存活率的关键。2002年通过美国食品药品管理局认证的CD4+T细胞内腺苷三磷酸含量检测技术(ImmuKnow技术)是目前最为便捷且成熟的评估免疫抑制人群细胞免疫功能状态的新途径。大量临床研究证实ImmuKnow检测结果与肝、肾、心脏、肠、胰腺移植受者的排斥反应事件、感染事件或临床稳定状态之间存在相关性。移植受者理想的ImmuKnow检测结果参考范围亦逐步明确。在实体器官移植中,ImmuKnow技术显示了预测感染和排斥反应风险的巨大应用前景。已有多个临床中心尝试依据ImmuKnow检测结果调整个体免疫抑制治疗方案并取得了初步的成果,其临床的推广应用尚需参照更多前瞻性研究、成本效益分析结果。A scientific monitory method of organ transplant recipients＇ immune function is the key of applying individualized immunosuppressive therapy and improving long-term survival. Immune function assay detecting CIM ＋T lymphocyte adenosine triphosphate level （ImmuKnow technology）, approved by the U. S. Food Drug Administration in 2002, so far, is the most convenient and mature method of cellular immune function assessment in the group of immunosuppressed people. A large number of clinical studies proved the correlations between the test results and rejection events, infections or clinical stability of liver, kidney, heart, intestines, and pancreas transplant recipients. The ideal ImmuKnow reference range has gradually been clear. In solid organ transplantation, the ImmuKnow technology showed great prospects of application in predicting the risk of infection or rejection. Several clinical centers have tried to adjust the individual immunosuppressive therapy based on the results of ImmuKnow tests and have gained initial success. The clinical value of the ImmuKnow technology has been confirmed in the initial studies, however, its further clinical application needs more evidence from clinical trials such as prospective studies and cost benefit analysis.

关 键 词：器官移植 免疫功能 CD4+ T淋巴细胞 腺苷三磷酸 ImmuKnow技术 感染 排斥反应 免疫监测 

分 类 号：R617[医药卫生—外科学]