碘化油乳剂经肝动脉化疗栓塞治疗消化道肿瘤肝转移的临床应用  

Clinical Application of Trans-hepatic Arterial Embolization with Lipiodol for Hepatic Metastasis from gastrointestinal cancer

作　　者：古善智[1] 李国文[1] 黄满平[1] 黄斌[1] 熊正平[1] 梁赵玉[1] 柴小立[1] 

机构地区：[1]湖南省肿瘤医院放诊科,湖南长沙410013

出　　处：《肿瘤药学》2011年第2期98-100,共3页Anti-Tumor Pharmacy

摘　　要：目的分析以碘化油化疗药乳剂经肝动脉化疗栓塞（transcatheter arterial chemoembolization,TACE）治疗消化道肿瘤肝转移的临床疗效。方法 28例消化道肿瘤肝转移患者,肿块最大径为7~16cm,经肝动脉灌注化疗并碘化油加化疗药物栓塞,碘化油用量为5～35ml,平均14.5ml,术后评估治疗的有效率、生存率、肿瘤标志物、并发症等。结果 TACE治疗的总有效率（RR）为64.3%（18/28）;治疗后6、12、18、24、36个月的生存率分别为100%（28/28）、80.1%（23/28）、64.3%（18/28）、28.6%（8/28）、10.7%（3/28）;治疗后67.9%（19/28）患者肿瘤标志物降低;介入术后均未出现严重并发症。结论碘化油化疗药乳剂经介入法肝动脉灌注化疗加上栓塞治疗消化道肿瘤肝转移的疗效较好,不良反应少。Objective To evaluate the treatment of TACE with Lipiodol for Hepatic Metastasis from gastrointestinal cancer. Method To retrospectively analyze 28 cases Trans-hepatic Arterial Embolization with Lipiodol for Hepatic Metastasis, Tumor maximal diameter 7~16cm, the average dosage of lipiodol was 14.5ml（5~35ml）. the Efficiency, survival, tumor markers, complications was evaluted after TACE. Results Results of 28 cases patient, the overall response rate was 64.3% （18/28）; the 6,12,18,24,36 month survival rates after treatment were 100% （28/28）、80.1%（23/28）、64.3%（18/28）、28.6%（8/28）、10.7%（3/28）; 19 cases of 28 cases patient’s tumor markers were descended（67.9%）; No severe complications happened in this series. Conclusion It is effective and safe for patients with Hepatic Metastasis from gastrointestinal cancer to receive TACE with lipiodol embolization.

关 键 词：碘化油 肝转移 肝动脉化疗栓塞 疗效 

分 类 号：R97[医药卫生—药品] R735[医药卫生—药学]