缓激肽选择性开放血脑屏障的机制探讨  

The mechanism of bradykinin selectively open the blood-brain barrier

作　　者：黄浩[1] 陈临溪[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001

出　　处：《肿瘤药学》2011年第4期330-333,共4页Anti-Tumor Pharmacy

摘　　要：血脑屏障在保护大脑的同时也限制了药物的转运。而脑肿瘤患者,其血脑屏障功能虽然不全,但脑肿瘤与血管之间存在血脑肿瘤屏障,很大程度上限制了化疗药物进入脑肿瘤组织。因此,在化疗时,提高血脑肿瘤屏障的通透性是提高化疗药物治疗效果的关键。本文就血脑屏障和血肿瘤屏障的结构特点、功能,以及缓激肽对血肿瘤屏障选择性开放的机制等研究进展做一综述。Blood-brain barrier supply protection for the brain,but it limits the transport of drugs.The function of blood-brain barrier of patients with brain tumor is deficient,but the blood-brain tumor barrier between the brain tumor and vessel limits the drugs across into brain tumor.It is crucial to enhance the permeability of the blood-brain tumor barrier to get a better result of treatment.This article review the mechanism of bradykinin selectively opening blood-brain tumor barrier,the structure and function of blood-brain barrier and blood-brain tumor barrier also is introduced.

关 键 词：缓激肽 血脑屏障 血瘤屏障 紧密连接 

分 类 号：R3[医药卫生—基础医学]