纤溶酶原激活物抑制物-1基因4G/5G多态性与冠心病的关联研究  

The association of plasminogen activator inhibitor-1 gene 4G/5G polymorphism with coronary heart disease

作　　者：赵晓辉[1] 刘鹏[1] 韩子强[2] 

机构地区：[1]泰山医学院附属医院心内一科,山东泰安271000 [2]泰山医学院继续教育学院培训部,山东泰安271000

出　　处：《中国现代医生》2012年第11期1-2,5,共3页China Modern Doctor

基　　金：泰山医学院青年科学基金(2010ZRQN024)

摘　　要：目的探讨纤溶酶原激活物抑制物-1(PAI-1)基因4G/5G多态性与冠状动脉疾病的关系。方法采用病例对照研究的方法。病例组146例,72例行冠状动脉造影证实患有CAD;正常对照组113例,选自人群健康体检者,所有入选病例均排除CAD史,脑卒中短暂性脑缺血发作病史及相似病史,排除周围血管疾病史。均用PCR-RFLP的方法判断各组基因型,最后进行统计学分析。结果与5G/5G相比,4G/5G,4G/4G的OR呈增加趋势,提示4G等位基因与冠心病的危险性相关。具有4G/4G基因型比具有5G/5G基因型的人患冠心病的危险性增加2.06倍(95%CI:1.03～4.14)。结论 PAI-1基因4G/4G基因型与中国汉族人群冠心病发生相关。Objective To investigate the association of the plasminogen activator inhibitor-1 gene 4G/5G polymorphism with coronary heart disease.Method We performed case-control study.The case group consisted of 146 patients some of them had all angiographically proved CAD.The control group consisted of 113 individuals who did not have a history of CAD.Stroke,transient ischemic attack,similar to cases,all of them were selected from healthy outpatients.We used PCR-RFLP method to decide the genotype of patients.At last we carried out statistical analysis.Results OR of the 4G/5G,4G/4G genotype is increasing comparing the 5G/5G genotype,then registering that it is sufficient association between the 4G/4G genotype and CHD.Fatalness enhanced 2.06 times in people with the 4G/4G genotype than people with the 5G/5G genotype（95%CI：1.03-4.14）.Conclusion There is significant association between the plasminogen activator inhibitor-1 gene 4G/4G polymorphism and coronary heart disease in china.

关 键 词：纤溶酶原激活物抑制物-1 基因多态性 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]