MR动态增强扫描评估正常兔肾实质的血流灌注  

Evaluation of renal blood perfusion in healthy rabbits with enhanced dynamic magnetic resonance

作　　者：刘铁滨[1] 王和平[1] 

机构地区：[1]湖南师范大学医学院临床医学系,湖南长沙410013

出　　处：《中国现代医生》2012年第11期53-54,共2页China Modern Doctor

基　　金：湖南省教育厅课题(08C567)

摘　　要：目的探讨动态增强磁共振检查对正常肾实质血流灌注评价的作用。方法健康大白兔9只,行肾脏动态增强MR检查,测量各肾皮质及髓质的信号强度,绘出其平均信号强度-时间曲线,记录皮质、髓质的平均峰值(P)及峰值/达峰时间比(P/T)。结果肾脏的灌注曲线(SI-T曲线)稳定,获得的血流灌注参数(Pc,Pm,Pc/Tc,Pm/Tm)具有一定规律,MR动态增强可反映出肾实质的血流动力学状态。结论动态增强MR能够反映肾脏血流灌注的变化,为兔肾血流动力学研究提供新的无创性手段。Objective To evaluate the renal blood perfusion in the healthy rabbits with dynamic contrast-enhanced MR technology.Methods Dynamic contrast-enhanced MR was performed in 9 healthy rabbits to obtain the mean signal intensity-time curves of both cortex and medulla of each kidney.Mean peak intensity value（P） and the P/Time to peak ratio at the cortex and medulla（Pc,Pm,Pc/Tc,Pm/Tm）of each kidney were measured.Results The renal perfusion curves（signal intensity time curve,SI-T curve）were stabl,and regularity was revealed in the blood perfusion parameters（Pc、Pm、Pc/Tc、Pm/Tm）.The renal hemodynamic information could be obtained with dynamic contrast-enhanced MR technology.Conclusion Dynamic contrast-enhanced MR scan can be used to assess the change of renal blood perfusion and provide new imaging methods for measuring the renal hemodynamics in healthy rabbits.

关 键 词：磁共振成像 肾脏灌注 血流动力学 

分 类 号：R445.2[医药卫生—影像医学与核医学]