冠心病病人血清VE-cadherin与hs-CRP浓度变化及意义  

CHANGES AND CLINICAL SIGNIFICANCE OF VASCULAR ENDOTHELIAL CADHERIN AND HYPERSENSITIVE C-REACTIVE PROTEIN IN PATIENTS WITH CORONARY HEART DISEASE

作　　者：郭庆波[1] 刘成玉[1] 

机构地区：[1]青岛大学医学院诊断学教研室,山东青岛266021

出　　处：《青岛大学医学院学报》2012年第2期143-145,147,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨冠心病(CHD)病人血清血管内皮细胞钙黏蛋白(VE-cadherin)和超敏C反应蛋白(hs-CRP)的变化及其意义。方法采用酶联免疫吸附法,测定20例急性心肌梗死(AMI)病人、20例不稳定型心绞痛(UAP)病人、20例稳定型心绞痛(SAP)病人血清VE-cadherin、hs-CRP浓度的变化,并与20例健康体检者进行比较。结果 CHD病人血清VE-cadherin、hs-CRP浓度明显升高,与对照组比较差异有显著性(t=6.02、6.27,P<0.01)。SAP组、UAP组和AMI组VE-cadherin和hs-CRP浓度依次升高,3组间比较,差异有显著性(F=35.66、36.12,q=4.56～9.83,P<0.01)。CHD病人血清VE-cadherin与hs-CRP浓度呈正相关(r=0.507,P<0.01)。AMI病人血清VE-cadherin、hs-CRP的ROC曲线下面积(AUCROC)分别为0.975、0.988,对AMI诊断的灵敏度和特异度分别为0.95、0.90和0.95、0.95;UAP病人的AUCROC分别为0.915和0.956,灵敏度和特异度分别为0.90、0.85和0.90、0.95;SAP病人的AUCROC分别为0.801、0.813。血清VE-cadherin、hs-CRP对于AMI、UAP病人有较高的诊断价值,且差异无统计学意义(u=0.357、0.195,P>0.05)。结论血清VE-cadherin和hs-CRP浓度的升高可能与冠状动脉病变程度相关,对CHD病变程度有较高的诊断价值。Objective To explore the changes and clinical significance of serum vascular endothelial cadherin（VE-cad） and hypersensitive C-reactive protein（hs-CRP） levels in patients with coronary heart disease（CHD）. Methods By using enzyme-linked immunosobent assay（ELISA）,VE-cad and hs-CRP were measured in 20 patients with acute myocardial infarction（AMI）,20 with unstable angina pectoris（UAP）,20 with stable angina pectoris（SAP） and 20 controls. Results The serum VE-cad and hs-CRP in CHD were higher than that in the controls（t=6.02,6.27;P〈0.01）.VE-cad and hs-CRP levels were increased in order of SAP,UAP and AMI,the differences among them were significant（F=35.66,36.12;q=4.56-9.83;P〈0.01）.In CHD,serum levels of VE-cad were positively correlated with hs-CRP（r=0.507,P〈0.01）.The area under the ROC curve（AUCROC） of VE-cad and hs-CRP was 0.975 and 0.988,respectively,and their sensitivity and specificity for diagnosis were 0.95,0.90 and 0.95,0.95,respectively.The AUCROC of VE-cad and hs-CRP in UAP was 0.915,0.956,and the sensitivity and specificity for diagnosis were 0.90,0.85 and 0.90,0.95.In SAP,the AUCROC of VE-cad and hs-CRP were 0.801,0.813.Serum VE-cad and hs-CRP had a relatively high diagnostic value for AMI,UAP,the difference between these two parameters was not significant（u=0.357,0.195;P〉0.05）. Conclusion The elevated serum levels of VE-cad and hs-CRP may be associated with the degree of coronary artery lesion,which is of a higher value in identification for the severity of CHD.

关 键 词：冠状动脉疾病 C反应蛋白 血管内皮细胞钙黏蛋白 诊断 

分 类 号：R541.4[医药卫生—心血管疾病]