谷氨酰转肽酶与老年高血压和高血压伴糖尿病患者心血管危险因素的关系探讨  

Plasma gamma-glutamyl transpeptidase level as a cardiovascular risk factor in elderly patients with hypertension or hypertension with diabetes mellitus

作　　者：吕雪英[1] 王招娣[1] 杨云梅[1] 徐哲荣[1] 

机构地区：[1]浙江大学医学院附属第一医院干部病房,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2012年第2期192-195,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省重大科技专项重点社会发展项目(2011C13032-2);国家"十一五"科技支撑计划研究项目(2006BAI02B08)

摘　　要：目的:探讨血浆γ-谷氨酰转肽酶(gamma-glutamyl transpeptidase,GGT)与老年高血压和高血压伴糖尿病患者心血管危险因素的相关性。方法:对49例老年高血压患者、42例高血压伴糖尿病患者及39例健康体检老年人,测量身高、体重、血压、血C反应蛋白(C-reactive protein,CRP)和生化全套,比较3组间心血管危险因素的关系,分析GGT与各组心血管危险因素的相关性。结果:3组之间GGT水平无明显差异;GGT与3组心血管危险因素的相关性分析显示,正常组GGT与收缩压(sistolic pressure,SBP)、脉压(pulse pressure,PP)、糖化血红蛋白(hemoglobin A1c,HbA1c)和CRP有显著正相关性,高血压伴糖尿病组GGT与收缩压、平均动脉压(mean arterial pressure,MAP)、空腹血糖(fasting blood sugar,FBG)和胱抑素(cystatin,Cys)有正相关。结论:GGT可能是心血管疾病的危险因子,也可能是高血压伴糖尿病患者早期肾损伤的预测指标。Objective： To investigate plasma gamma-glutamyl transpeptidase（γ-GGT） level as a cardiovascular risk factor in elderly patients with hypertension or hypertension with diabetes mellitus.Methods： Forty-nine elderly patients of hypertension and 42 elderly patients of hypertension with diabetes mellitus and 39 healthy elderly subjects were enrolled in the study.The height,weight and blood pressure of patients were measured,serum C reactive protein and other biochemical indicators were detected.The relation between plasma γ-GGT and cardiovascular risk factors in three groups were analyzed.Results： There was no significant difference in plasma γ-GGT levels among three groups.There was a positive correlation of plasma γ-GGT levels with systolic pressure,pulse pressure,hemoglobin A1c and CRP in control group.While in hypertension with diabetes mellitus group,plasma γ-GGT levels were correlated with systolic pressure,mean arterial pressure,fasting blood sugar and cystatin.Conclusions： Plasma γ-GGT might be a risk factor for cardiovascular diseases,and may be used as a predictive indicator for kidney injury in early patients with hypertension with diabetes mellitus.

关 键 词：γ-谷氨酰转移酶/血液 高血压/并发症 危险因素 糖尿病并发症 谷氨酰转肽酶 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]