阿扎司琼等预防全麻妇科腹腔镜术后寒战100例对比观察  

The efficacy of Azasetron for the preventing postoperative Shivering in patients undergoing gynecological laparoscopic surgeries under general anaesthesia

作　　者：肖永[1] 李元涛[1] 陈桂珊[1] 吴铭广[1] 谷寅[1] 孙晶[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院麻醉科,深圳518028

出　　处：《陕西医学杂志》2012年第1期72-75,共4页Shaanxi Medical Journal

摘　　要：目的:探讨阿扎司琼与曲马多、哌替啶在预防全身麻醉妇科腹腔镜术后寒战的临床效果。方法:将100例ASA I～II级,拟行妇科全麻腹腔镜择期手术患者随机分为4组,每组25例。A组(阿扎司琼0.15mg/kg),T组(曲马多1mg/kg),P组(哌替啶0.4mg/kg)和对照组(0.9%生理盐水);手术结束时静脉注射给药,记录各组寒战、苏醒及不良反应发生情况。结果:与对照组比较阿扎司琼与曲马多、哌替啶一样可明显减少术后寒战的发生率(P<0.05);阿扎司琼组的苏醒与拔管时间明显短于曲马多组和哌替啶组(P<0.05),不良反应的发生率也少于曲马多组和哌替啶组(P<0.05)。结论:阿扎司琼与曲马多、哌替啶一样用于预防全麻术后寒战是安全可行的。Objective：To investigate the efficacy of azasetron on post-anaesthesia shivering of gynecological laparoscopic surgeries under general anaesthesia.Methods：100ASA I ～ Ⅱ patients undergoing elective surgery were randomly assigned to four groups（each group n=25） using a double-blinded protocol.Group A received 0.15mg/kg azasetron IV,group T received 1mg/kg tramadol IV,group P received 0.4mg/kg pethidine IV,and group C received saline 0.9% IV as placebo.All drugs were administered immediately after the end of operation.Record the occurrence of shivering,the recovery time and the adverse effects after these drugs administered.Results：To compare to placebo,Azasetron reduced the incidence of post-anaesthetic shivering as significantly as tramadol and pethidine.Recovery time of group A was shorter than of group T and group P（P0.05）.The incidence of the adverse effects in group A was lower than of group T and group P（P0.05）.Conclusion：At the end of operation azastron infusion is effective and safe in the prevention of post-anaesthetic shivering.

关 键 词：麻醉 全身 寒战/副作用 寒战/预防和控制 血清素拮抗药/治疗应用曲 马朵/治疗应用 哌替啶/治疗应用 对比研究 腹腔镜检查 手术后期间 

分 类 号：R614.2[医药卫生—麻醉学]