PDGFR-α在继发性骨髓纤维化骨髓组织中表达的研究  

Expression and significance of platelet-derived growth factor in PMF

作　　者：梁漫[1] 何春玲[2] 王越月[2] 田亚宁[2] 周智辉 张云志[2] 闫昱江[2] 刘芳[2] 董昌虎[2] 

机构地区：[1]陕西中医学院 [2]陕西中医学院第二附属医院血液科,咸阳712000

出　　处：《陕西医学杂志》2012年第2期140-141,209,共3页Shaanxi Medical Journal

基　　金：陕西省教育厅专项科研计划项目(NO:09JK390)

摘　　要：目的:探讨血小板衍化生长因子受体-ɑ(PDGFR-ɑ)在继发性骨髓纤维化骨髓组织中的表达及临床意义。方法:应用免疫组化染色法,检测继发性骨髓纤维化组、对照组骨髓组织中PDGFR-α的表达情况。结果:继发性骨髓纤维化组骨髓组织中PDGFR-α的表达明显高于对照组,差异有统计学意义(P<0.05)。结论:PDGFR-α可能与继发性骨髓纤维化的发生、发展存在一定关联。Objective：To investigate the clinical significance and expression of platelet-derived growth factor receptor-alpha（PDGFR-α） in Secondary bone marrow fibrosis.Methods：Using immuno biochemical staining to test the expression of PDGFR-α in 30 Secondary bone marrow fibrosis,24 contrast.Results：The PDGFR-α was highly increased in Secondary bone marrow fibrosis than contrast.Conclusion：The PDGFR-α was highly expressed in Secondary bone marrow fibrosis than contrast,the PDGFR-α may be associated with secondary myelofibrosis occurrence,development relationship.

关 键 词：骨髓纤维化 继发 血小板衍化生长因子 骨髓 

分 类 号：R551.3[医药卫生—血液循环系统疾病]