血糖波动对糖尿病大鼠心肌组织中转化生长因子β_1的影响  

Effects of blood glucose fluctuants on TGF-β_1 in myocardium of diabetic rats

作　　者：杨智勇[1] 张微[2] 赵晟[3] 尹照萍 贾晨红[1] 

机构地区：[1]中国医科大学附属盛京医院心内科,沈阳110004 [2]中国医科大学附属第四医院内分泌科 [3]北京电力医院心内科 [4]辽宁省盘锦市辽河油田妇婴医院内科

出　　处：《陕西医学杂志》2012年第4期387-389,共3页Shaanxi Medical Journal

基　　金：辽宁省科学技术基金(2009225010-18)

摘　　要：目的:探讨血糖波动对糖尿病大鼠心肌组织中转化生长因子β1(TGF-β1)的影响。方法:雄性Wistar大鼠30只,分为对照组,波动性高血糖组,持续性高血糖糖组,饲养8周后,取血测定血管紧张素Ⅱ浓度,测定心肌组织中TGF-β1的表达。结果:波动性高血糖糖尿病大鼠心肌组织内TGF-β1的表达及血管紧张素Ⅱ的含量显著高于持续性高血糖组及对照组。结论:糖尿病时血糖波动对心肌细胞的影响,要强于平稳的高血糖状态。Objective：To investigate the effects of blood glucose fluctuants on TGF-β1 in myocardium of diabetic rats.Methods： 30 Wistar rats were divided into 3 groups：normal control group,fluctuant high blood glucose group and stable high blood glucose group.After 8 experimental weeks,the level of Angiotensin Ⅱ and the express of TGF-β1 in the myocardium were investigated.Results：The level of Angiotensin Ⅱ and the express of TGF-β1 were significantly higher than that of stable high blood glucose group and the control group（P0.05）.Conclusion：Glucose fluctuation can be more deleterious to myocardial cell than stable high blood glucose.

关 键 词：糖尿病 血糖 转化生长因子Β 动物 实验 大鼠 

分 类 号：R587.1[医药卫生—内分泌]