原发性高尿酸血症患者血小板α-颗粒膜蛋白、血小板活化因子及血小板参数的变化  

Changes of Platelet α-Particle Membrane Protein,Platelet Activating Factor and Platelet Parameters in Patients with Hyperuricemia

作　　者：丁丹丹[1] 王伟[1] 崔中光[1] 汪洪毅[1] 

机构地区：[1]青岛大学医学院附属医院血液内科,山东青岛266003

出　　处：《中国实验血液学杂志》2012年第2期394-397,共4页Journal of Experimental Hematology

摘　　要：本研究探讨原发性高尿酸血症(HUA)患者血小板α-颗粒膜蛋白(GMP-140)、血小板活化因子(PAF)及血小板参数的变化。采用酶联免疫方法测定55例HUA患者及30例健康体检者外周血GMP-140、PAF水平;应用全自动血液分析仪测定HUA患者及健康体检者血小板参数,并检测其他生化指标。结果表明:HUA组的尿酸、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均高于对照组(P<0.01),HUA组的男性血尿酸水平高于女性,HUA组GMP-140、PAF水平明显高于对照组(P<0.01),HUA组大血小板比率(P-LCR)、血小板体积分布宽度(PDW)明显高于对照组(P<0.05),血小板计数、血小板平均体积(MPV)、血小板压积(PCT)与正常对照组比较差异均无显著性差异。血尿酸分别与PAF、GMP-140、P-LCR、PDW之间呈正相关(r值分别为0.667、0.879、0.310、0.460,P<0.01或P<0.05)。以GMP-140为因变量的逐步回归分析显示,尿酸、肌酐、P-LCR尿素氮进入回归模型(调整后R2=0.822);以PAF为因变量的逐步回归分析显示,尿酸、低密度脂蛋白胆固醇进入回归模型(调整后R2=0.451)。结论:HUA与血小板功能改变关系密切,在心血管疾病血栓性并发症的发生中起着一定的作用。This study was aimed to investigate the changes of the platelet particle membrane protein（GMP-140）,platelet activating factor（PAF） and platelet parametes in the patients with hyperuricemia（HUA）,ELISA was used to detect the levels of GMP-140 and PAF in 55 patients with HUA and 30 healthy individuals.Platelet parameters were measured with automatic blood cell analyzer,and the biochemical indexes were detected at the same time.The results showed that the levels of serum uric acid,triglycerides（TG） and low density lipoprotein cholesterol（LDL-C） in HUA patients were higher than that in the normal group（P0.01）.Serum uric acid level of HUA group was higher in men than that in women.The levels of GMP-140 and PAF in HUA patients were much higher than that in the normal group（P0.01）,the indexes of platelet distribution width（PDW）and platelet-large cell ratio（P-LCR） in HUA patients were higher than that in the normal group（P0.01）,there was no statistically significant difference in platelet count,plateletcrit（PCT）,mean platelet volume（MPV） between the two groups.There was positive correlation between serum uric acid and levels of GMP-140,PAF,P-LCR and PDW,respectively（r=0.667,0.879,0.310,0.460,P0.01 or P0.05）.Multivariate stepwise regression analysis revealed that serum uric acid,creatinine,P-LCR,urea nitrogen contributed to GMP-140 level（adjusted R2=0.822）.Serum uric acid and LDL-C also contributed to PAF level（adjusted R2=0.451）.It is concluded that a close relationship exists between HUA and the change of platelet function,and HUA plays a certain role in cardiovascular disease thrombosis complications.

关 键 词：高尿酸血症 GMP-140 血小板活化因子 血小板参数 

分 类 号：R589.9[医药卫生—内分泌]