胎儿纤维连接蛋白检测联合宫颈长度测量对预测早产的临床观察  

Clinical observation of fetal fibronectin detection combined with cervical length measurement in predicting preterm birth

作　　者：肖丽萍[1] 王爱梅[1] 

机构地区：[1]上海市浦东新区南汇中心医院妇产科,上海201300

出　　处：《中国医药导报》2012年第11期70-71,共2页China Medical Herald

摘　　要：目的探讨宫颈分泌物胎儿纤维连接蛋白(fFN)与宫颈长度联合测量预测早产的价值。方法对有先兆早产症状的80例孕妇进行阴道后穹窿分泌物fFN的检测和宫颈阴道超声测量,追踪其妊娠结局。结果①80例先兆早产孕妇,fFN阳性34例,阳性率为42.5%,28例发生早产,早产率为82.4%,与fFN阴性组比较,差异有统计学意义(P<0.05),48 h,7 d,37周内分娩的阴性预测值分别为100.0%、100.0%、84.8%。②超声测量受检者宫颈长度,宫颈长度≤30 mm为异常,35例异常者中26例发生早产(74.3%);与宫颈长度正常组比较,差异有统计学意义(P<0.05),fFN阳性同时宫颈长度异常预测早产发生的敏感性为80.8%,特异性为96.9%,阳性预测值为95.5%,阴性预测值为93.9%。结论fFN是预测早产的客观指标,联合宫颈长度测量可以提高对先兆早产孕妇发生早产的阳性预测和阴性预测结果,提高早产预测的准确率。Objective To investigate the value of fetal fibronectin（fFN） in the cervical secretions detection combined with cervical length（CL） measurement in predicting the threatened preterm labor.Methods 80 pregnant women with symptoms of threatened premature labor underwent fFN and CL testing.The pregnant outcomes were tracked.Results ①Among 80 subjects,positive fFN was detected in 42.5%（34 cases）.The incidence of preterm birth was 82.4%,the difference was significant compared to the group with negative fFN（P 0.05）.The negative predictive value of delivery within 48 hours,7 days and 37 weeks were 100.0%,100.0% and 84.8%.②CL was measured in all 80 cases,the CL≤30 mm was abnormal.There were positive diagnosis of 35,actual premature labor 26（74.3%）,the difference was significant compared to the group with normal CL（P 0.05）.The sensitivity,specificity,positive predictive value and negative predictive value of positive fFN and abnormal CL for preterm birth were 80.8%,96.9%,95.5% and 93.9% respectively.Conclusion Cervical fFN is an objective indicator in predicting preterm labor.The detection of fFN combined with the measurement of CL can improve the positive and negative predictive values in predicting spontaneous preterm birth.

关 键 词：胎儿纤维连接蛋白 宫颈长度 早产 预测 

分 类 号：R714[医药卫生—妇产科学]