Bioinformatic prediction of selenoprotein genes in the dolphin genome  被引量:1

Bioinformatic prediction of selenoprotein genes in the dolphin genome

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作  者:CHEN Hua JIANG Liang NI JiaZuan LIU Qiong ZHANG JiHong 

机构地区:[1]College of Life Sciences,Shenzhen University,Shenzhen 518060,China [2]College of Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China [3]Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao 266071,China

出  处:《Chinese Science Bulletin》2012年第13期1533-1541,共9页

基  金:supported by the National Natural Science Foundation of China (31070731);the Natural Science Foundation of Guangdong Province (10151806001000023)

摘  要:Selenium (Se), an essential trace element in vivo, is present mainly as selenocystein (Sec) in various selenoproteins. The Sec residue is translated from an in-frame TGA codon, which traditionally functions as a stop codon. Prediction of selenoprotein genes is difficult due to the lack of an effective method for distinguishing the dual function of the TGA codon in the open reading frame of a selenoprotein gene. In this article a eukaryotic bioinformatic prediction system that we have developed was used to predict selenoprotein genes from the genome of the common bottlenose dolphin, Tursiops truncatus. Sixteen selenoprotein genes were predicted, including selenoprotein P and glutathione peroxidase. In particular, a type II iodothyronine deiodinase was found to have two Sec residues, while the type I iodothyronine deiodinase gene has two alternative splice forms. These results provide important information for the investigation of the relationship between a variety of selenoproteins and the evolution of the marine-living dolphin.Selenium (Se), an essential trace element in vivo, is present mainly as selenocystein (Sec) in various selenoproteins. The Sec residue is translated from an in-frame TGA codon, which traditionally functions as a stop codon. Prediction of selenoprotein genes is difficult due to the lack of an effective method for distinguishing the dual function of the TGA codon in the open reading frame of a selenoprotein gene. In this article a eukaryotic bioinformatic prediction system that we have developed was used to predict selenoprotein genes from the genome of the common bottlenose dolphin, Tursiops truncatus. Sixteen selenoprotein genes were predicted, including selenoprotein P and glutathione peroxidase. In particular, a type II iodothyronine deiodinase was found to have two Sec residues, while the type I iodothyronine deiodinase gene has two alternative splice forms. These results provide important information for the investigation of the relationship between a variety of selenoproteins and the evolution of the marine-living dolphin.

关 键 词:生物信息学 硒蛋白P 蛋白基因 预测系统 宽吻海豚 基因组 谷胱甘肽过氧化物酶 终止密码子 

分 类 号:Q811.4[生物学—生物工程] Q513

 

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