糖尿病心肌病发病机制,靶点和中药治疗  

Mechanisms and Therapeutic Targets of Traditional Chinese Medicine(TCM) in Treating Diabetic Cardiomyopathy

作　　者：伏鹏荣[1] 丛晓东[1] 张云[1] 蔡宝昌[1,2] 

机构地区：[1]浙江中医药大学中药炮制技术研究中心,浙江杭州310053 [2]南京中医药大学江苏省中药炮制重点实验室,江苏南京210049

出　　处：《现代生物医学进展》2012年第6期1179-1182,共4页Progress in Modern Biomedicine

基　　金：科技部国家重大新药创制计划(NO:2009ZX09308)

摘　　要：高血糖诱发心肌代谢紊乱,引起心肌肥大和纤维化,使心脏舒张和收缩功能发生异常,诱发心衰,造成糖尿病心肌病。其病理过程可能与心肌中激活NADPH氧化酶、内质网应激、内皮素和活性氧通路等炎症因子有关。本文综述糖尿病心肌病的主要机制,相关靶点及中药治疗,为中药治疗糖尿病提供理论依据。Hyperglycemia induces myocardial metabolism disorder,causing myocardial hypertrophy and fibrosis,then diastolic and systolic dysfunction and heart failure occur,resulting in diabetic cardiomyopathy（DC）.The pathological process may involve multi-ple mechanisms and targets,including activation of NADPH oxidase,endoplasmic reticulum stress and the endothelin-reactive oxygen species pathway in the myocardium.The main mechanisms and targets of DC are reviewed to provide the theoretic considerations in treating DC with TCM.

关 键 词：糖尿病心肌病 靶点 中药治疗 氧化应激 炎症因子 细胞保护 

分 类 号：R587.2[医药卫生—内分泌]