多发性肌炎肌组织中Th17细胞的浸润  

The Infiltration of Th17 Cells in Muscle Tissues of Polymyositis

作　　者：韩文娟[1] 张红鸭[1] 康娟[1] 胡萌萌[1] 贾宏阁[1] 

机构地区：[1]第四军医大学附属西京医院神经内科,陕西西安710032

出　　处：《现代生物医学进展》2012年第7期1277-1279,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(81171181)

摘　　要：目的:探讨多发性肌炎(PM)患者肌肉炎性组织中是否存在Th17细胞及数量多少。方法:临床和病理诊断确诊的多发性肌炎患者16例;对照组来自非炎性肌病患者6例。应用免疫荧光组织化学方法检测Th17淋巴细胞的定位及数量。结果:与非肌炎患者比较,免疫荧光组织化学检测到肌炎患者肌肉组织中IL-17表达阳性,主要分布在细胞内,且细胞数量的多少与炎症的严重程度成正相关。结论:Th17细胞有可能参与了多发性肌炎的发病过程。Objective： To investigate the existence and quantities of Th17 cells in the muscle tissue of patients with polymyositis.Methods： 16 patients with polymyositis after a diagnosis of clinical and pathological;control group is 6 patients from non-inflammatory myopathy.Detect the location and the number of IL-17-producing effector T helper cells through immunofluorescence.Results： Compared to non-inflammatory myopathy,IL-17 positively expresses in patients with polymyositis which is mainly in cells,and the number of Th17 cells is positively related to the severity of inflammation.Conclusions： The Th17 cells may be involved in the pathogenesis of polymyositis.

关 键 词：多发性肌炎 TH17细胞 白细胞介素17(IL-17) 

分 类 号：R593.2[医药卫生—内科学]