血清胱抑素C检测在ICU急性肾损伤中的意义  

The Application of Cystatin C(Cys C) in Valuation Acute Kidney Injury in ICU Patients

作　　者：邹德勇[1] 耿红艳[2] 王秀梅[1] 赵怡雯[1] 张小丽[1] 翁泽兵[1] 刘兰兰[1] 赵海滨[1] 郭晓今[1] 刘向祎[2] 

机构地区：[1]武警总医院检验科,北京100039 [2]首都医科大学附属北京同仁医院检验科,北京100730

出　　处：《现代生物医学进展》2012年第7期1300-1302,共3页Progress in Modern Biomedicine

基　　金：北京市临床生化参考测量体系的建立及应用(2009-1045)

摘　　要：目的:测定ICU的急性肾损伤(AKI)患者和ICU非AKI患者的血清胱抑素C(Cys C)、Cr及β2-MG的水平,研究Cys C在AKI中的应用价值。方法:采用日立7600-120全自动生化分析仪测定ICU AKI患者31例和ICU非AKI患者24例的Cys C、Cr、β2-MG,用受试者工作曲线(ROC)评价Cys C的诊断价值,采用spss 16.0统计软件包进行统计分析。结果:ICU的AKI患者的血清Cys C水平较ICU非AKI对照组升高,有统计学意义,[Cys C]-1与eGFR呈正相关,r=0.711,P<0.001;与AKI分期无统计学意义。ROC曲线分析证实Cys C在AKI的诊断中敏感性和特异性最好。结论:血清Cys C可以做为ICU病人发生AKI的诊断指标,为AKI的及时诊断、肾功能的评估提供了可靠的依据,有助于临床更好的把握治疗时机。Objective： To explore the application of Cystatin C（Cys C） in valuation acute kidney injury in ICU Patients.Methods： In this study,55 patients were collected and divided into two groups,including 31 cases with AKI and 24 cases without AKI as controls.We measured the serum concentration of Cys C,β 2-MG,and Cr by HITACHI 7600-120 Automatic biochemical analyzer.The eGFR was estimated the with MDRD equation.Then compared Cys C、Cr、β 2-MG between two groups and the correlations with each other.The diagnostic value of Cys C were evaluated by ROC curve with SPSS 16.0 software.Results： In AKI group,The serum level of Cys C were significantly higher than that in non-AKI group（P0.05）,it has no significant difference among three periods（P0.05）.-1 was also positively correlated with eGFR（r=0.711,P0.001）.The ROCAUR of Cys C is 0.930.Conclusions： Cys C is a very useful diagnostic indicator in AKI,especially in the early diagnose AKI,it could provide a reliable assessment of renal function and grasp the right opportunity to better treatment.

关 键 词：胱抑素C 急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学] R446.6[医药卫生—外科学]