门诊慢性HBV感染者初次就诊的临床诊断亚类构成比分析  

Analysis of the constituent ratio and its clinical diagnostic subtypes for patients with chronic HBsAg infection in their first outpatient visit

作　　者：方清[1,2] 李磊[1] 张振华[1] 王俊忠[1] 马德强[1] 陈明发[1] 康健[1] 郝友华[1] 杨东亮[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030 [2]三峡大学第一临床医学院宜昌市中心人民医院

出　　处：《内科急危重症杂志》2012年第2期98-101,共4页Journal of Critical Care In Internal Medicine

基　　金：国家传染病防治科技重大专项资助(No:2008ZX10002-011)

摘　　要：目的:了解门诊就诊的慢性乙型肝炎不同临床诊断亚类患者的构成比及其变化趋势。方法:通过门诊电子病历获取肝病门诊2007～2009年3年期间初次就诊慢性HBV感染者的临床信息,统计分析9类慢性HBV感染者临床诊断亚类的构成比及其3年的变化趋势。结果:3年期间共有2677例门诊初次就诊的慢性HBV感染者,其诊断分类构成比依次为:HBeAg阳性慢性乙型肝炎32%;非活动HBsAg携带者24.1%;HBeAg阴性慢性乙型肝炎23.9%;慢性HBV携带者12.1%;HBeAg阴性代偿性肝硬化4.4%;乙肝相关性原发性肝癌1.4%;HBeAg阳性代偿性肝硬化0.9%;乙肝合并其他疾病0.6%;失代偿性乙肝后性肝硬化0.4%。3年期间各亚类患者构成比及排序保持相对稳定,其中HBeAg阳性慢性乙型肝炎患者构成比有逐年下降趋势,HBeAg阴性慢性乙型肝炎构成比有逐年上升趋势;各诊断类型患者的平均年龄与HBV自然史保持一致;男/女患者比例约2.55。结论:慢性乙型肝炎和携带者是肝病门诊慢性HBV感染者的就诊主体,HBeAg阳性慢性乙型肝炎患者构成比有逐年下降趋势,可能是受我国乙肝疫苗接种计划的影响。Objective ：To investigate the constituent ratio and its variation trend of different clinical diagnostic subtypes for patients with chronic HBsAg infection in their first outpatient visit. Methods ：Through the database the clinical informations of patients with chronic HBsAg infection in the initial diagnosis during 2007 - 2009 were obtained. The constituent ratio and its variation trend of different diagnostic subtypes for patients with 9 chronic HBsAg infection were statistically analyzed. Results ：There were 2 677 outpatients with initial diagnosis of chronic HBsAg infection during 3 years, the constituent ratio of the different diagnostic classification are ranked by HBeAg positive chronic hepatitis B in 32% ,inactive HBsAg carriers in 24.1% ,HBeAg negative chronic hepatitis B in 23.9% ,chronic HBV carriers in 12.1% , HBeAg negative compensatory cirrhosis in 4.4% , hepatitis virus related hepatocellular carcinoma in 1.4% , ftBeAg positive decompensated cirrhosis in 0.9%, hepatitis B complicated with other diseases in 0.6% , decompensated liver cirrhosis in 0.4%. During the 3 years, the type constituent ratio and sorting remained relatively stable,with HBeAg positive chronic hepatitis B patients constituent ratio present downtrend of year after year,while HBeAg negative chronic hepatitis B constituted an increasing tendency year by year;the mean age of patients and HBV natural history maintained consistent in each type. Conclusions：Chronic hepatitis B and chronic HBV carriers are the main body in outpatients. The constituent ratio of patients with HBeAg positive chronic hepatitis B has downtrend of year after year,this may be affected by the hepatitis B vaccination project in our country.

关 键 词：慢性乙型肝炎 门诊 患者 

分 类 号：R512.62[医药卫生—内科学]