燃煤污染型氟中毒对人群生化电解质水平的影响  

Blood chemistry and electrolyte effects of exposure to fluoride from burning coal on population

作　　者：梁超轲[1] 张淑兰[2] 李文华[1] 马凤[1] 吴云鹏[1] YLi BPKatz EJBrizendine GKStorkey3.? 

机构地区：[1]中国预防医学科学院环研所,北京100050 [2]天津市卫生防病中心 [3]美国印第安纳大学牙科学院 [4]美国印第安纳大学医学院

出　　处：《中国地方病学杂志》2000年第1期47-50,共4页Chinese Jouranl of Endemiology

基　　金：美国 NIH/ NID-PHS研究基金! PO1DE0 93 85

摘　　要：目的　探讨燃煤污染型氟中毒人群与正常人群之间的生化电解质水平有无差异。方法　选择燃煤重度中毒病区 2个村 ,与无室内燃煤氟污染的 2个对照村。每个村检测农民 119～ 12 2人 ,即氟中毒 2 47人 ,无氟中毒农民 2 41人 ,男女各半 ,年龄 35～ 6 0岁。采样测定环境氟水平 ,计算每人每日总摄氟量 ,同时检查氟斑牙 ,右前臂拍 X片诊断氟骨症。应用自动生化分析仪分析血清中 16项生化电解质水平 ,即钾、钠、氯、钙、磷、葡萄糖、尿素氮、尿酸、肌酐、总蛋白、白蛋白、谷草转氨酶、肌酸肌酶、碱性磷酸酶、总胆红素和总胆固醇。以 ANOVA方法进行方差分析。结果　研究结果表明 ,2个氟中毒村每人日总摄氟量为 6 .5 7mg和 8.5 4m g,氟斑牙患病率为92 .86 %与 99.0 2 % ,氟骨症患病率为 14.81%和 14.13% ,2项指标均属正常范围 ,且无氟骨症发生。结论　燃煤污染氟中毒人群与正常人群生化电解质水平均属正常范围。血清碱性磷酸酶活性随氟中毒加重而升高 ,血钾水平随氟中毒加重而升高 。Objective The purpose of this investigation was to determine the various levels of blood chemistry and electrolyte in human at suffering burning coal fluorosis.Methods Four groups of Chinese with different fluoride exposure from burning coal were selected from four rural villages,119 to 122 local residents in each group.Fluoride exposure of each study population was determined by analysis of fluoride in food,drinking water and indoor air using a combined fluoride specific electrode.Sixteen biochemical parameters (K,Na,Cl,Ca,P,Glu,Urea,Uric,Crea,TP,ALB,AST,CK,ALP,TbiL and Chol) of each blood sample from each subject was analyzed by Automatic Analyzer.Results The survey results indicate that total daily intake fluoride 6.57 and 8.54 mg/d,dental fluorosis prevalence rate 92.86% and 99.02%,skeletal fluorosis rate by X ray 44.44% and 95.00 % for two burning coal fluorosis groups respectively,as well as daily total intake fluoride 2.42 and 2.48mg/d,dental fluorosis prevalence rate 14.81% and 14.13%,no skeletal fluorosis for two control groups respectively.Conclusions All monitored values were within normal range,and no significant differences were found among groups,but a little increase for alkaline phosphatase activity and potassium with the more fluoride intake was discovered.Their effects do not appear to be clinically significant. [

关 键 词：氟中毒 血液 生化 电解质 燃煤型 

分 类 号：R599.9[医药卫生—内科学]