5种常用广谱β内酰胺类抗生素的体外抗菌活性比较  

Comparison Study on the In Vitro Antimicrobial Activity of Five Common Used Broad spectrum Beta lactams

作　　者：施光峰[1] 翁心华[1] 陈为欢[2] 尹有宽[1] 阮斐怡 吕元[2] 

机构地区：[1]上海医科大学华山医院传染病科,上海200040 [2]上海医科大学华山医院检验科,上海200040

出　　处：《上海医科大学学报》2000年第1期61-63,共3页Journal of Fudan University(Medical Science)

摘　　要：目的　比较５种常用广谱β内酰胺类抗生素的抗菌活性。方法　用Ｅｔｅｓｔ方法测定各抗生素对１００株细菌的最低抑菌浓度。结果　所测５种抗生素对受测菌的总敏感性依次为：亚胺培南９４％，头孢哌酮／舒巴坦７６％，头孢他啶６８％，头孢曲松６５％，哌拉西林３８％。结论　亚胺培南几乎可覆盖所有致病菌，且其抗菌活性最高；头孢他啶对革兰阴性杆菌的抗菌活性明显优于革兰阳性菌，尤其对铜绿假单孢菌的活性是其优势。Purpose To evaluate the antimicrobial activity of five broad spectrum beta lactams in common use. Methods Employing E test method to determine the minimum inhibiting concentration(MIC)of antibiotics against 100 strains bacteria. Results The rank order of susceptibility of the five antimicrobial agents was imipenem(94%),cefoperazone/sulbactam (76%),ceftazidime (68%),ceftriaxone (65%),piperacillin (38%). Conclusions Imipenem is the most active antimicrobial agent that almost against all bacteria;the antimicrobial activity of ceftazidime against aram negative rods is more active than that against gram positive cocci,especially,predominantly against Pseudomonas aeruginosa.

关 键 词：Β内酰胺类 抗生素 抗菌活性 微生物敏感试验 

分 类 号：R978.11[医药卫生—药品]