肝炎肝硬化患者脂联素测定及胰岛素抵抗指数测定的临床意义  

The Clinical Significance of Adiponectin and HOMA-IR in Posthepatitic Cirrhosis

作　　者：谢丽[1] 李群[1] 窦雯雯[2] 苏艳[1] 

机构地区：[1]潍坊医学院传染病学教研室,山东潍坊261053 [2]潍坊医学院附属医院传染科

出　　处：《潍坊医学院学报》2012年第2期93-95,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 研究脂联素（ADP）及胰岛素抵抗指数（HOMA-IR）在肝炎肝硬化患者血清中的表达水平,并探讨其在肝炎肝硬化疾病中的临床意义.方法 严格按照诊断标准选取肝炎肝硬化患者43例,同时选取13例健康查体人员为参照.取受试者清晨的空腹血,应用酶联免疫法（ELISA）检测血清 ADP 水平,并测定空腹血糖（FPG）、空腹血清胰岛素水平（FINS）,计算HOMA-IR.结果 ①肝炎肝硬化患者血清 ADP 水平明显高于对照组（P＜0.05）,脂联素浓度从Child-Pugh A级、B级和C级呈依次递增趋势.②在健康对照组、肝炎肝硬化组患者间FPG无显著性差异（P〉0.05）,FINS水平及HOMA-IR值肝炎肝硬化组明显高于健康对照组;在肝炎肝硬化患者组Child分级间,FPG差异无明显统计学意义（P〉0.05）,FINS和HOMA-IR与Child分级正相关,随Child分级的升高而明显升高.③在肝炎肝硬化组,按均数大小顺序血清脂联素水平、FINS及HOMA-IR均是C〉B〉A.肝炎肝硬化患者血清脂联素水平与FINS及HOMA-IR 呈正相关（P〈0.05）.结论 肝炎肝硬化患者血清脂联素及胰岛素抵抗水平均明显升高,其在肝硬化的发展中起到重要的作用,并且其两者之间存在相互关联.Objective To discover the relationship between ADP and HOMA-IR in posthepatitic cirrhosis patients,and to investigate the relationship in the disease progression. Methods The forty-three cases of posthepatitic cirrhosis and 13 cases health control as the observation group were selected. Fasting blood was collected,the serum ADP was measured by ELISA, and FPG, FINS by machine. Then the HOMA-IR was calculated. Results （1）The serum ADP levels of posthepatitic cirrhosis were significantly higher than those of health control group （ P 〈 0.05 ）. Among cirrhosis patients, ADP concentration from the Child-Pugh A, B, and C level was followed by an increasing trend. （2） FPG has no significant difference between the health group and posthepatitic cirrhosis group （ P 〉 0.05 ） , and was also in posthepatitic cirrhoSis grading（ P 〉0.05 ）. But FINS and HOMA-IR level of the posthepatitic cirrhosis group was significantly higher than healthy control group （ P 〈 0.05 ）. The FINS and HOMA-IR of posthepatitic cirrhosis patients was positively related to Child grading of liver function and was sig- nificantly higher with the increase of Child grading. （3）In the posthepatitic cirrhosis group, according to the mean size of the order of serum ADP, FINS and HOMA-IR were C 〉 B 〉 A. The ADP level of posthepatitic cirrhosis was positively correlated with FINS and HOMA-IR （ P 〈 0.05 ）. Conclusion The ADP and HOMA-IR in posthepatitic cirrhosis are significantly high, and they play an important role in the development of posthepatitic cirrhosis. And there is a correlation between the two.

关 键 词：乙型肝炎 肝炎肝硬化 CHILD-PUGH分级 脂联素 胰岛素抵抗 

分 类 号：R512.62[医药卫生—内科学]