慢性乙型肝炎患者血清瘦素水平在肝纤维化发病中的意义  

Serum Leptin Levels in Patients with Chronic Hepatitis B and the Correlation with Hepatic Fibrosis

作　　者：苏艳[1] 李群[1] 窦雯雯[2] 谢丽[1] 

机构地区：[1]潍坊医学院传染病学教研室,山东潍坊261053 [2]潍坊医学院附属医院感染性疾病科

出　　处：《潍坊医学院学报》2012年第2期96-98,共3页Acta Academiae Medicinae Weifang

摘　　要：目的 通过测定慢性乙型肝炎患者血清瘦素水平,研究其在肝纤维化发病过程中的意义.方法 采用酶联免疫法测定45例慢性乙型肝炎患者和30例对照者血清瘦素和肝纤维化血清学指标：透明质酸（HA）、Ⅲ型前胶原（PCⅢ）、Ⅳ型胶原（Ⅳ-C）和层粘蛋白（LN）的水平.结果 慢乙肝组患者的血清瘦素水平显著高于对照组（P〈0.01）;在对照组、慢乙肝组中女性瘦素水平明显高于男性（P〈0.01）;瘦素水平和HA,PCⅢ,Ⅳ-C,LN呈正相关（P〈0.01）.结论 慢性乙型肝炎患者的血清瘦素水平将会明显升高;女性瘦素水平高于男性,有性别差异;肝纤维化程度与血清瘦素水平存在正相关.Objective To study the significance in the progress of liver fibrosis,through determining the serum leptin levels in patients with chronic hepatitis B. Methods The levels of serum leptin and serum markers of liver fi- brosis ： hyaluronic acid （HA）, Ⅲ procollagen （ PC Ⅲ ）, Ⅳ collagen （ⅣV-C ） and laminin （ LN ） level were measured by ELISA（ enzyme linked immunoassay）. Results The serum leptin levels of chronic hepatitis B patients were significantly higher than control group（ P 〈 0.01 ） ;In the control group and chronic hepatitis B group, leptin levels of women were sig- nificantly higher than men （ P 〈 0.01 ） ; The leptin levels and HA, PC Ⅲ, IV-C, LN were positively correlated （ P 〈 0.01 ）. Conclusion The serum leptin levels of patients with chronic hepatitis B will significantly elevated;the leptin levels are higher in women than men, gender differences is existed ; the level of liver fibrosis and the serum leptin levels are positivly correlated.

关 键 词：乙型肝炎 慢性 瘦素 肝纤维化 

分 类 号：R512.6[医药卫生—内科学]