急性乙型肝炎患者外周血CD28分子的表达  

The Study of the Expression of CD28 on Lymphocyte in Acute Hepatitis B Patients

作　　者：李蕾[1] 张小茜[1] 高志星[2] 张红梅[2] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊医学院附属医院消化内科

出　　处：《潍坊医学院学报》2012年第2期102-103,共2页Acta Academiae Medicinae Weifang

摘　　要：目的 探讨CD28分子在急性乙型肝炎发病过程中的表达机制.方法 按病人选取标准选取40例病人和10例健康查体者,每例取外周血5ml,应用流式细胞仪检测病人外周血中CD28＋细胞所占比率.应用ELISA法检测急性乙型肝炎之间CD28＋/CD8＋T,CD28＋/CD4＋T表达的差异.结果 急性乙型肝炎病人CD28＋细胞所占比例显著高于健康对照组和慢性乙型肝炎组,差别有统计学意义（P＜0.01）.结论 急性乙型肝炎病人CD28分子表达强弱与HBV感染密切相关,CD28＋ 淋巴细胞对清除HBV感染有重大意义.Objective To discuss the mechnism of T helper cells and their cytokines in patients with Acute hepatitis B. Methods Forty patients and ten healthy volunteers were chosen strictly. Five millilitres peripheral blood from each person was taken. The production of CD28＋ T in all these specimens was detected by ELISA. Results The proportion of CD28＋ T lymphocyte in Acute hepatitis B group was larger than that of the healthy control group, but it was smaller than that of HBeAg positive CHB group （P 〈 0.01 ）. The proportion of CD28＋ T lymphocyte in the AHB group was the largest in the four groups. Conclusion The disbalance of cell immunity and humoral immunity was existed in the Acute hepatitis B patients. The amounts of cytokins from Thl cells have close relationship with the inflammatory activity of liver infected by HBV.

关 键 词：乙型肝炎 急性 乙型肝炎 慢性 CD28 

分 类 号：R512.62[医药卫生—内科学]