药物洗脱支架植入术联合氯吡格雷治疗冠心病的临床疗效  

The effects of drug-eluting stents combined clopidogrel on patients with coronary artery disease

作　　者：谢阳[1] 吴强[1] 吴敏[1] 陈扬波[1] 徐名伟[1] 林宇鹏[1] 

机构地区：[1]揭阳市人民医院心内科,广东揭阳522000

出　　处：《中国老年学杂志》2012年第8期1557-1559,共3页Chinese Journal of Gerontology

基　　金：揭阳市卫生局医学科研立项项目(No.B200706)

摘　　要：目的探讨药物洗脱支架(DES)植入术联合氯吡格雷治疗冠心病的临床疗效。方法回顾性分析2007年1月至2011年12月,该院收治的73例接受经皮冠状动脉介入治疗(PCI)的患者,对照组(DES治疗术后,除了常规二级预防以外,服用氯吡格雷12个月)28例,观察组(DES治疗术后,除了常规二级预防外,服用氯吡格雷18个月)45例。比较两组治疗2年后急性心血管事件的再发生率、再次住院率、死亡率的差别。结果对照组与观察急性心血管事件发生率(10.7%vs 4.4%,P=0.001)、再次住院率(14.3%vs 4.4%,P=0.001)、晚期血栓发生率(14.3%vs 6.3%,P=0.001)比较差异显著,有统计学意义;死亡率(0%vs 0%,P=0.95)比较差异无统计学意义(P>0.05)。两组患者治疗后血液流变学指标显著优于治疗前,差异有统计学意义(P<0.05);观察组治疗后血液流变学指标明显优于对照组,差异有统计学意义(P<0.05)。远期观察疗效良好。结论 DES植入联合氯吡格雷对冠心病治疗效果良好,值得推广。Objective To explore the clinical curative effect of drug-eluting stents（DES） implantation combined clopidogrel on coronary heart disease（CHD） patients.Methods 73 CHD patients who underwent percutaneous coronary intervention（PCI） were divided into control group（treated with clopidogrel for 12 months,28 cases） and observation group（treated with clopidogrel for 18 months,45 cases）.After treated for 2 years,the incidence of acute cardiovascular events,the rate of again to the hospital,mortality were compared.Results The incidence of acute cardiovascular events（10.7% vs 4.4%,P=0.001）,the rate of again to the hospital（14.3% vs 4.4%,P=0.001）,late incidence of thrombosis（14.3% vs 6.3%,P=0.001） had no significant differences between two groups.After treated,the blood flow indexes of two groups were significantly better than those before treatment,and they were better in observation group than those of control group Long-term effect was good.Conclusions The effect of DES implantation combined clopidogrel treatment CHD is good,and it is worthy to be popularized.

关 键 词：药物洗脱支架 金属裸支架 氯吡格雷 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]