S100A8蛋白在炎症中的作用  

S100A8 protein in inflammation

作　　者：徐玉东[1] 尹磊淼[1] 王宇[1] 魏颖[1] 杨永清[1] 

机构地区：[1]上海中医药大学,上海市针灸经络研究所,上海200030

出　　处：《生理学报》2012年第2期231-237,共7页Acta Physiologica Sinica

基　　金：supported by the National Natural Science Foundation of China(No.81173332;30873299;81001548;81173341);the Innovation Program of Shanghai Municipal Education Commission(No.09ZZ128);the Shanghai Leading Academic Discipline Project(No.S30304);the Key Program of State Administration of Traditional Chinese Medicine of China

摘　　要：S100A8是一种具有保守的EF-hand结构域的低分子量(10.8kDa)钙结合蛋白,也是S100蛋白家族的重要成员。研究表明S100A8蛋白功能与包括哮喘在内的许多炎症性病理过程密切相关。S100A8蛋白主要通过对中性粒细胞的趋化作用激活炎症细胞和炎性因子、结合并活化膜受体晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)和Toll样受体4(Toll-like receptor4,TLR4),从而介导细胞内的炎症信号转导等途径,在炎症中发挥重要的调节作用。此外,也有研究显示S100A8蛋白具有抗炎症活性,表明S100A8在不同的病理生理条件下可能发挥更为复杂的生物学调节功能。本文对S100A8蛋白在炎症中的作用及其分子机制的研究进展作一综述,为哮喘等炎症性疾病的防治提供新思路。S100A8,an important member of the S100 protein family,is a low-molecular-weight （10.8 kDa） calcium-binding protein containing conserved EF-hand structural motifs.Previous studies have shown that the biological function of S100A8 protein is associ-ated with a variety of inflammatory diseases,for example asthma.S100A8 protein plays important roles in the regulation of inflamma-tion.It can activate inflammatory cells and cytokines via chemotactic activity for neutrophils,and bind to the receptor for advanced glycation end products （RAGE） and Toll-like receptor 4 （TLR4）,thus mediating intracellular inflammatory signaling transduction.Additionally,recent studies have reported the anti-inflammation activity of S100A8 protein,which indicates that S100A8 may have a more complex function of biological regulation in the different pathophysiological conditions.In this review,we summarized the stud-ies on the functions and molecular mechanisms of S100A8 protein in inflammation,which would propose a novel strategy for the pro-phylaxis and treatment of asthma and other inflammatory diseases.

关 键 词：S100A8 炎症 信号转导 哮喘 

分 类 号：R392.1[医药卫生—免疫学]