T细胞相关趋化因子及受体的研究进展  

Progress in the research of chemokine and chemokine receptor of T cells

作　　者：周灵[1] 彭代智[1] 

机构地区：[1]第三军医大学第一附属医院烧伤研究所,重庆400038

出　　处：《免疫学杂志》2012年第5期449-454,共6页Immunological Journal

摘　　要：T细胞在发育、成熟、活化及发挥生物学效应的各个阶段表达不同的趋化因子受体。T细胞相关趋化因子及其受体的表达在不同的细胞类群上具有时相和分布的差异,并通过趋化因子与其受体特异性结合的模式,参与T细胞的发育过程,调控细胞的定向迁移,从而影响局部甚至整个机体的免疫状态。此外,它还在炎症、感染、肿瘤、自身免疫疾病等众多病理生理的过程中发挥重要作用。在这一领域的深入研究将为相关疾病的预防和治疗提供新的思路和途径。T cells express various chemokine receptors in the different stages of their generation,maturation,activation and biological function.Chemokines and their receptors are expressed differently during distinct developmental stages in the various cell subsets.They are involved in lymphocyte development and regulate the migration of immunocytes to specific regions in the manner of special binding between chemokines and their corresponding receptors.Therefore,they would affect the immune state of local or the whole organism.In addition,they play an essential role in pathophysiologic processes of the inflammation,infection,tumor and autoimmune diseases etc.Further studies in this field would have not only revealed new targets for the related diseases and have also uncovered the new pathes for the prevention and treatment for the diseases.

关 键 词：T细胞 趋化因子 趋化因子受体 趋化作用 

分 类 号：R392.9[医药卫生—免疫学]