应用实时心肌超声造影定量评价心功能对急性心肌梗死犬心肌血流量的影响  

Real-time myocardial contrast echocardiography evaluates the effection of cardiac function on myocardial blood flow of acute myocardial infarction in mongrel

作　　者：吕静[1] 丁尚伟[2] 王静[2] 张艳容[2] 李秀兰[1] 王淑彬[1] 吕清[2] 

机构地区：[1]湖北潜江江汉油田总医院超声科湖北潜江,433124 [2]华中科技大学协和医院超声影像科

出　　处：《临床心血管病杂志》2012年第4期292-294,共3页Journal of Clinical Cardiology

基　　金：国家自然科学基金资助(No:30872422);国家教育部新教师基金资助(No:2007-0487-162)

摘　　要：目的:探讨心功能对心肌梗死犬心肌血流灌注的影响。方法:18只健康杂种犬于前降支分出的第1对角支远端约1cm处结扎3h,应用心肌超声造影(MCE)定量分析左室前壁中间段和下壁中间段心肌血流量(MBF)。结果:17只犬成功建立急性心肌梗死模型。根据结扎3h后左室整体射血分数(EF)分为2组:A组(EF≥50%)7只,B组(EF<50%)10只。B组左室前壁中间段和下壁中间段MBF均低于A组,但2组之间差异无统计学意义;与结扎前相比,2组左室前壁中间段MBF均明显降低,差异有统计学意义(P<0.05),A组左室下壁中间段MBF略升高,B组则降低,但均差异无统计学意义。结论:心功能对MBF有一定的影响,可能会低估冠状动脉血流储备和高估狭窄程度,在以MCE诊断冠心病时应注意心功能对MBF的影响。Objective：To investigate the effect of cardiac function on myocardial perfusion of the mongrel＇s acute myocardial infarction model.Method：Eighteen dogs were performed the acute myocardial infarction models by ligating the left anterior descending（LAD） 3 hours,then the contrast agent（C3F8） was injected into femoral vein to perform myocardial contrast echocardiography（MCE） examination,and quantitative calculate the myocardial blood flow（MBF） both of left ventricle middle-anterior wall and middle-posterior wall.Result：Seventeen dogs are successfully performed acute myocardial infraction models.Three hours after ligating LAD,in the A group（n=7） the eject fraction of left ventricle ≥50%,the MBF of middle-anterior wall is obviously lower than the one before ligating LAD（P0.01）,but the MBF of middle-posterior wall is only a litter higher than that before ligating LAD（P0.05）;in the B group（n=10） the eject fraction of left ventricle 50%,the MBF of middle-anterior wall is also obviously lower than the one before ligating LAD（P0.01）,the MBF of middle-posterior wall is slightly lower than that before ligating LAD（P0.05）;Between A group and B group after 3-hour ligating LAD,the MBF of both middle-anterior wall and middle-posterior wall in B group are only slightly lower than those in A group.Conclusion：The cardiac function can influence MBF sometines and maybe induce to undervalue the coronary reserve of flow and overmeasure the narrow degree of coronary,it＇s helpful to consider the cardiac function＇s effection using MCE to diagnosis coronary disease.

关 键 词：心功能 心肌超声造影 心肌血流量 

分 类 号：R540.4[医药卫生—心血管疾病]