肾上腺髓质素在自发性高血压大鼠中的动态变化  

Dynamic changes of adrenomedullin in spontaneous hypertensive rats

作　　者：欧燕芳 邓祖国[2] 黎兴平 罗衡丽 莫开勇[2] 田培燕[2] 

机构地区：[1]贵州省黔南州中医院贵州都匀,558000 [2]贵州省黔南民族医学高等专科学校

出　　处：《临床心血管病杂志》2012年第4期306-307,共2页Journal of Clinical Cardiology

基　　金：州省教育厅科研基金(No:黔科教2007091);南民族医学高等专科学校科研基金(No:QNYZ2007006)

摘　　要：目的:了解肾上腺髓质素(ADM)在自发性高血压大鼠模型中第8周、12周、18周和24周的动态变化,以探讨其可能的作用机制及病理生理意义。方法:随机抽取6周雄性自发性高血压大鼠及Wistar各40只为实验组和对照组,分别于第8周、12周、18周和24周,各随机抽取10只迅速麻醉后心脏取血,测定各时点血浆ADM浓度。结果:实验组和对照组ADM差异有统计学意义[第8周(55.42±2.63)ng/L∶(26.86±2.80)ng/L,第12周(120.80±3.23)ng/L∶(29.17±2.20)ng/L],[第18周(160.90±3.14)ng/L∶(31.53±1.86)ng/L,第24周(222.70±8.80)ng/L∶(32.99±2.26)ng/L]。结论:ADM在自发性高血压发生后明显增高。Objective：To explore the dynamic change of adrenomedullin（ADM） in spontaneous hypertensive rats in the 8th,12th,18th and 24th weeks,in order to probe into its possible functional mechanisms and pathophysiological significance.Method：Randomly choose 40 6-week-old male rats with spontaneously hypertension and 40 Wistar rats as experimental group and control group respectively.Rats were conducted rapidly anesthesia and were taken blood from heart for detecting ADM in the 8th,12th,18th and 24th weeks.Result：ADM was significantly higher in the experimental group than which in the control group [the 8th week（55.42±2.63）ng/L∶（26.86±2.80）ng/L,the 12th week（120.80±3.23）ng/L∶（29.17±2.20）ng/L],[the 18th week（160.90±3.14）ng/L∶（31.53±1.86）ng/L,the 24th week（222.70±8.80）ng/L∶（32.99±2.26）ng/L].Conclusion：ADM increases in rats with spontaneous hypertension.

关 键 词：自发性高血压 肾上腺髓质素 大鼠 动态变化 

分 类 号：R544.1[医药卫生—心血管疾病]