3-羟-3甲基戊二酰辅酶A还原酶基因多态与血浆高浓度低密度脂蛋白的风险  

3-hydroxy-3-methylglutaryl Coenzyme A Reductase Gene Polymorphism and the Risk of High Concentration of Plasma Low-density Lipoprotein

作　　者：赵治国[1] 张庆英[1] 易德青[1] 蔡应木[2] 方晔 罗家逸[1] 

机构地区：[1]汕头大学医学院公共卫生与预防医学教研室 [2]汕头大学医学院第一附属医院检验科,广东汕头515041 [3]汕头市潮南民生医院检验科,广东汕头515144

出　　处：《汕头大学医学院学报》2012年第1期4-7,共4页Journal of Shantou University Medical College

基　　金：广东省科技计划资助项目(2011B031800209)

摘　　要：目的:研究潮汕人群3-羟-3甲基戊二酰辅酶A(HMG-CoA)还原酶基因多态性与血浆高浓度低密度脂蛋白(LDL)的风险。方法:收集潮汕籍汉族高浓度LDL 792例,并与1 073名健康人对照,用SNPstream技术检测样本HMG-CoA还原酶基因多态性。结果:2个单核苷酸多态性位点(rs3846662和rs12916)与高浓度LDL均有相关性(P<0.05),2个单倍型G-T-C和A-C-C在两组中的分布差异有统计学意义(P<0.05)。结论:HMG-CoA还原酶2个单核苷酸多态性和2个单倍型均与血浆高浓度低密度脂蛋白LDL存在相关性。Objective： To investigate 3-hydroxy-3-methylglutaryl eoenzyme A（HMG-CoA）reductase gene polymorphism and the risk of high concentration of plasma low-density lipoprotein in Chaoshan population. Methods： One thousand and seventy-three controls and 792 eases in Chaoshan Han population were enrolled. HMG-CoA reductase gene polymorphisms were genotyped by SNPstream genotyping system. Results： Two single nucleotide polymorphisms （rs3846662 and rs12916） were associated with high concentration lipopmtein （ P 〈 0.05）. The distribution of two haplotypos （G-T-C and A-C-C） was also significantly different between two groups （P 〈 0.05）. Conclusion： Two single nucleotide polymor- phisms and two haplotypes are associated with high risk of high concentration of low-demity lipoprotein.

关 键 词：3-羟-3甲基戊二酰辅酶A还原酶 低密度脂蛋白 基因多态性 

分 类 号：R589.2[医药卫生—内分泌]