急性心肌梗死患者心室血栓与血小板体积和数量的相关性  

Mean platelet volume and platelet count in patients with left ventricular thrombus after acute myocardial infarction

作　　者：景林德[1] 李彦[1] 贾友宏[1] 

机构地区：[1]中国医学科学院 北京协和医学院 阜外心血管病医院 卫生部心血管药物临床研究重点实验室,100037

出　　处：《中国心血管杂志》2012年第2期86-88,共3页Chinese Journal of Cardiovascular Medicine

基　　金："重大新药创制"科技重大专项<创新药物临床研究技术平台建设>(2008ZX09312-018)~~

摘　　要：目的分析急性心肌梗死(AMI)患者并发左心室血栓与平均血小板体积(MPV)和血小板计数(PLT)的相关性。方法回顾性分析2007年1月至2011年4月在阜外心血管病医院住院治疗的69例AMI并心室血栓形成患者,及138例与之年龄匹配(1∶2)的无心室血栓形成的AMI患者。比较两组患者入院时和入院后第6～8天两个时间点的MPV和PLT变化特点,以及分析MPV和PLT的相关性。结果两组患者入院时MPV差异无统计学意义[(10.3±1.0)fl比(10.3±0.8)fl,P=0.854],入院后第6～8天心室血栓组患者的MPV明显高于无心室血栓组[(11.1±1.7)fl比(10.7±0.7)fl,P=0.029]。入院时和入院后第6～8天PLT在两组间差异均无统计学意义(P=0.587、0.807)。入院后第6～8天患者MPV与PLT的关联表现为线性关系。结论 AMI患者MPV增大可能与心室血栓形成相关。Objective To determine whether mean platelet volume （MPV） and platelet count （PLT） were associated with left ventricular thrombus （LVT） after acute myocardial infarction （ AMI ）. Methods The 207 consecutive patients with AMI were included： 69 LVT cases and 138 no LVT age matched controls. Blood samples were collected for MPV and PLT measurements on admission and at the 6- 8th day after admission. Results MPV did not differ between patients with LVT and controls [ （ 10.3 ± 1.0）fl vs. （ 10. 3 ± 0. 8） t, P = 0. 854] on admission, but MPV was significantly higher in LVT cases compared with controls [ （ 11.1 ± 1.7） fl vs. （ 10. 7 ± 0. 7） t, P = 0. 029 ] at the 6-8th day after admission. Neither PLT on admission nor at the 6-8th day after admission showed a difference between LVT cases and controls. There is a linear relationship between MPV and PLT at the 6-8 th day after admission in all patients. Conclusions MPV has a close association with the formation of LVT after AMI.

关 键 词：急性心肌梗死 心室血栓 平均血小板体积 血小板计数 

分 类 号：R542.22[医药卫生—心血管疾病]