幽门螺旋杆菌感染与绝经前女性缺铁性贫血的相关性  

Relationship between Helicobacter Pylori Infection and Iron Deficiency Anemia of Pre-menopause Female

作　　者：连小赟[1] 王一[1] 牛倩[1] 苗玉迪[1] 翟欣辉[1] 张玎[1] 王岐山[1] 

机构地区：[1]陕西省人民医院血液科,西安710068

出　　处：《现代检验医学杂志》2012年第1期31-33,共3页Journal of Modern Laboratory Medicine

基　　金：基金项目：陕西省社发攻关项目2009K18-01.

摘　　要：目的研究幽门螺旋杆菌（HP）感染与绝经前女性缺铁性贫血（IDA）的相关性。方法收集陕西省人民医院2009年2月～2011年3月门诊及住院绝经前女性IDA患者154例及健康门诊体检绝经前女性87例，采用金标法检测血清HP尿素酶抗体。将HP阳性患者随机分为2组，其中1组（39例）及HP阴性组（76例）给予补铁治疗，2组（39例）给予补铁＋清除HP治疗。所有患者治疗前、治疗后2周、4周复查血常规及血清铁蛋白。结果①154例女性IDA患者，HP阳性78例，感染率50．65％；对照组87例，HP阳性32例，感染率36．79％。二者相比差异具有统计学意义（P〈0．05）；②血清铁蛋白在治疗4周后HP阳性2组明显高于1组（0．005〈P〈0．01）及HP阴性组（P〈0．001）。结论幽门螺旋杆菌感染可能是缺铁性贫血的病因之一，有效地清除HP治疗能提高铁储存，从而可能提高这些1DA患者的疗效。Objective To determine the correlation between Iron Deficiency Anemia（IDA） and Helicobacter pylori（HP） infection in pre-menopause female. Methods Collect 154 cases of pre-menopause female iron deficiency anemia outpatient and inpatient and 87 cases of healthy female outpatient for physical examination from February 2009 to March 2011 from Shaanxi Province People＇s Hospital. The incidence of HP infection was detected by serum urease antibody. The patients of IDA associated with HP positive was divided into two groups in random. Group 1（39 cases） and HP negative group（76 cases） were given iron alone,group 2（39 cases） were given eradication of HP infection and iron. Routine blood test and serum ferritin （SF） were measured pre and post treatment in the study groups on the second and fourth week. Results （DThe cases of HP positive in the study group was 78（infection rate 50. 65 % ） and in the control group was 32（infection rate 36.79 % ）, the two groups had significance statistical difference （P〈0. 05）. （2）After 4 weeks of therapy, SF of HP positive group 2 was significantly higher than group 1（0. 005〈P〈0.01）and HP negative group（ P〈0. 001）. Conclusion HP infection would be one of a cause of iron deficiency anemia（IDA）. The eradication of HP could significantly increase iron stores, thus may increase curative effect of IDA patients.

关 键 词：缺铁性贫血 幽门螺旋杆菌 血清铁蛋白 

分 类 号：R378.3[医药卫生—病原生物学] R556.3[医药卫生—基础医学]