血吸虫病患者的肝抗原IgG谱及肝功能检测研究  

Analysis of Liver Antigen lgG Spectrum in the Patients with Schistosomiasis

作　　者：张家均[1] 王娴默[1] 雷鸿斌[1] 黄娥[1] 雷选斌[1] 郭辉[1] 董虹[1] 

机构地区：[1]荆州市第一人民医院暨长江大学附属第一医院,湖北荆州434000

出　　处：《现代检验医学杂志》2012年第1期115-116,119,共3页Journal of Modern Laboratory Medicine

摘　　要：目的研究血吸虫病患者是否有肝自身免疫性抗体存在。方法收集来自荆州市第一人民医院住院的100例血吸虫病患者的血清，运用免疫印迹法检测肝抗原IgG谱，同时运用全自动生化分析仪检测其肝功能，并综合分析其结果。结果100例血吸虫病患者肝抗原IgG谱显示，LKM-1，LC-1及sLA／LP均为阴性，但有21例血吸虫病患者AMA—M2阳性；对AMA—M2阳性和阴性患者血清肝功能进行比较发现，血清ALT，AsT，ALP及rGT差异有统计学意义（P〈0．05），其t值分别为7．115，6．685，7．219和8．398。结论血吸虫病患者可以出现肝自身免疫性抗体，且AMA—M2阳性患者往往伴随肝功能损伤。Objective To investigate whether the patients with schistosomiasis had autoimmune antibodies of liver or not. Methods According to the method of Western blot,spectrum of liver antigen IgG were tested in serum collected from clini- cal patients of schistosomiasis,and liver function of these patients were tested by automatic biochemical analyzer as well. Results According to the results of spectrum of liver antigen IgG in 100 cases of schistosomiasis patients,LKM-1,LC-1 and SLA/LP were all negative, but 21 patients were AMA-M2 positive. Compared with AMA-M2-negative patients, Serum ALT, AST,ALP and γ-GT of AMA-M2 positive patients were significantly different with AMA-M2 positive patients （P〈 0.05） ,and the value of t were 7. 115,6. 685,7. 219 and 8. 398, respectively. Conclusion Autoimmune antibodies of liver could occur in patients with schistosomiasis,of which the AMA-M2 positive were always accompanied with liver injury.

关 键 词：丙酮酸脱氢酶复合物 血吸虫病 肝纤维化 

分 类 号：R532.21[医药卫生—内科学] R446.112[医药卫生—临床医学]