我国四川、广西、新疆地区女性性工作者对暴露前预防用药预防HIV感染接受意愿调查  

Investigation on acceptability of pre-exposure prophylaxis among female sex workers in Sichuan,Xinjiang and Guangxi of China

作　　者：邱蕾[1] 田考聪[1] 钟晓妮[1] 张燕[1] 彭斌[1] 梁浩[2] 邹云锋[3] 罗锦昆 彭鸿斌 黄爱龙[5] 

机构地区：[1]重庆医科大学公共卫生学院卫生统计学教研室,重庆400016 [2]广西医科大学公共卫生学院流行病与卫生统计学教研室,南宁530021 [3]广西医科大学公共卫生学院毒理学教研室,南宁530021 [4]四川省南充市顺庆区疾病预防控制中心,南充637000 [5]重庆医科大学感染性疾病分子生物学教育部重点实验室,重庆400016

出　　处：《上海交通大学学报（医学版）》2012年第4期508-513,共6页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家科技重大专项项目(2008ZX10001-016)~~

摘　　要：目的了解我国四川省、新疆维吾尔自治区、广西壮族自治区女性性工作者(FSWs)对暴露前预防用药(Pr-EP)预防人类免疫缺陷病毒(HIV)感染的接受意愿及其影响因素。方法采用问卷调查的形式,调查对象为四川省、新疆维吾尔自治区、广西壮族自治区的FSWs。调查完成问卷1 478份,有效问卷1 469份(占99.39%)。调查内容主要为FSWs对Pr-EP的知晓情况和接受意愿。结果经调查人员介绍了Pr-EP相关知识后,在Pr-EP安全有效的前提下,共有801人(54.5%)表示"肯定愿意使用",有196人(13.3%)表示"可能会使用",Pr-EP使用意愿为67.9%(997/1469),三个地区间的差异无统计学意义(P>0.05)。经过单因素χ2检验和Logistic回归分析,结果显示:Pr-EP的接受意愿的影响因素包括危险自评(OR=1.776,P=0.005)、性服务安全套使用(OR=1.346,P=0.000)、最近三次发生性交易使用安全套的频率(OR=1.519,P=0.003)、是否使用过药物预防性病(OR=1.185,P=0.025)、是否拒绝与不使用安全套的人发生性行为(OR=1.479,P=0.009)、是否会建议朋友接受Pr-EP(OR=5.618,P=0.000)。三个地区FSWs对Pr-EP比较关注的是其安全性/不良反应、效果/有效性、费用。结论坚持使用安全套的FSWs更倾向于接受Pr-EP;应该加大Pr-EP相关知识的宣传力度,提高FSWs对Pr-EP知晓率,进一步提高FSWs对于Pr-EP的接受意愿;同伴教育可能是推广Pr-EP的有效方式。Objective To investigate the acceptability and influencing factors of pre-exposure prophylaxis（Pr-EP） for human immunodeficiency virus（HIV） among female sex workers（FSWs） in Sichuan,Xinjiang and Guangxi of China.Methods FSWs selected from Sichuan,Xinjiang and Guangxi were surveyed with questionnaires.A total of 1 478 questionnaires were completed,among which 1 469（99.39%） were effective.The survey mainly concerned with the awareness and acceptability of FSWs on Pr-EP.Results After introduction to Pr-EP by the investigators,under the precondition that Pr-EP was effective and safe,997（67.9%） FSWs accepted Pr-EP,and there was no significant difference in the acceptability among FSWs in three regions（P0.05）.Univariate χ2 analysis and Logistic regression analysis revealed that self-evaluation of risks（OR=1.776,P=0.005）,regular condom use in sex service（OR=1.346,P=0.000）,frequency of condom use during the latest three times of sex service（OR=1.519,P=0.003）,drug use to prevent sexually-transmitted disease（OR=1.185,P=0.025）,refusal of having sex with those without condom use（OR=1.479,P=0.009） and advising peers to use Pr-EP（OR=5.618,P=0.000） were influencing factors of acceptability of Pr-EP.FSWs mainly concerned of the security,effectiveness and cost of Pr-EP.Conclusion FSWs with regular condom use are more likely to accept Pr-EP.Pr-EP related knowledge should be well exposed among FSWs to increase the awareness and acceptability.Peer education may be a better way to improve the acceptability of Pr-EP.

关 键 词：人类免疫缺陷病毒 女性性工作者 暴露前预防用药 接受意愿 

分 类 号：R183.9[医药卫生—流行病学]