肺结核患者血清IL-4、IL-6和TGF-β测定及其临床意义  

Detection and clinical significance of serum IL-4,IL-6,and TGF-β cytokines in patients with pulmonary tuberculosis

作　　者：张孝侠[1] 赵长峰[2] 

机构地区：[1]济宁医学院医学检验系,山东济宁272013 [2]山东大学营养与食品卫生学教研室

出　　处：《中国病原生物学杂志》2012年第3期195-196,219,共3页Journal of Pathogen Biology

摘　　要：目的探讨肺结核患者血清IL-4、IL-6、TGF-β水平及其临床意义。方法采用酶联免疫吸附试验测定42例肺结核患者及28例健康人血清IL-4、IL-6、TGF-β水平,并进行t检验和线性相关分析。结果肺结核患者血清IL-4为(0.56±0.72)pg/ml,健康对照组为(0.21±0.07)pg/ml,差异有统计学意义(P<0.05);肺结核组血清IL-6、TGF-β为(0.06±0.04)pg/ml、(0.10±0.07)pg/ml,健康对照组为(0.07±0.05)pg/ml、(0.10±0.06)pg/ml,差异均无统计学意义(P>0.05);复治组与初治组TGF-β含量比较差异有统计学意义(t=2.39,P<0.05)。肺结核患者血清IL-4、TGF-β的含量呈正相关(r=0.90,P<0.05)。结论肺结核患者血清IL-4、TGF-β含量升高,可能参与结核病的免疫过程;检测IL-4、TGF-β对肺结核的诊断有一定价值。Objective To explore the clinical significance and levels of serum IL-4,IL-6,and TGF-β in patients with pulmonary tuberculosis（TB）.Methods Serum IL-4,IL-6,and TGF-β in 42 patients with TB and 28 healthy controls selected were determined with ELISA,and a t-test and linear correlation analysis were performed.Results The level of serum IL-4 differed significantly（P〈0.05） in patients with TB（0.56±0.72） pg/ml and healthy controls for（0.21±0.07） pg/ml,while the levels of the other 2 cytokines did not.The level of TGF-β differed significantly（t = 2.39,P〈0.05） in repeatedly treated and initially treated patients.Levels of serum IL-4 and TGF-β were correlated in patients with TB（r=0.90）.Conclusion Increased levels of serum IL-4 and TGF-β in patients with TB indicated their possible involvement in the immune response to TB,and their detection is of some value in diagnosing TB.

关 键 词：肺结核 IL-4 IL-6 TGF-Β 

分 类 号：R521[医药卫生—内科学]