绿原酸对内毒素致热的影响  

Effect of Chlorogenic Acid on the Fever Induced by Endotoxin

作　　者：张炳仁[1] 马文惠[1] 陈宝[1] 何丽钦[1] 

机构地区：[1]沈阳药科大学,辽宁沈阳110016

出　　处：《辽宁中医药大学学报》2012年第5期229-231,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探索绿原酸是否是双黄连发挥解热作用的物质基础。方法:在给家兔静脉注入内毒素造成的发热模型上,评价绿原酸对发热家兔体温的影响。结果:绿原酸表现出退热作用,呈现明显的量效和时效关系,但起效时间较长。结论:绿原酸是双黄连发挥解热作用的物质基础。Objective：To investigate whether chlorogenic acid is the material basis to play the role of antipyretic effect in Shuanghuanglian and other drugs.Methods：Rabit fever model was setup by the administration of endotoxin,then the effect of chlorogenic acid on the fever was studied.Results：Chlorogenic acid had antipyretic effect and it＇s antipyretic effect showed obvious relationship between dose and time.However,it had a longer onset time.Conclusion：Chlorogenic acid is the material basis to play the role of antipyretic effect in Shuanghuanglian and other drugs.

关 键 词：绿原酸 内毒素 解热作用 

分 类 号：R453[医药卫生—治疗学]