戊巴比妥钠对兔定量药物脑电图δ和θ频段的影响  

Effects of sodium pentobarbital on δ-band and θ-band of quantitative pharmaco-electroencephalography in rabbits

作　　者：韩平平[1] 蔡慧明[1] 胡志超[2] 孔莉[2] 周美艳[1] 张明阳 刘亚君[3] 郭继龙[4] 吴克俭[4] 戴体俊[3] 

机构地区：[1]徐州医学院药学院,江苏省221002 [2]商丘市第一人民医院麻醉科 [3]徐州医学院麻醉学院,江苏省221002 [4]徐州医学院附属医院

出　　处：《江苏医药》2012年第8期872-874,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(30872432;30471657;39970715);徐州医学院药学院研究生科研创新计划项目(2010YKYCX011);商丘市科技攻关计划项目(20103005)

摘　　要：目的观察戊巴比妥钠对兔定量药物脑电图(QPEEG)δ、θ频段的影响。方法采用QPEEG功率谱分析法观察家兔静脉注射戊巴比妥钠30mg/kg前后δ、θ频段功率百分比的变化。结果与基础值相比,各脑区在给药后30s、1、2、3、5、10min时的δ频段功率百分比均增大,而θ频段功率百分比均降低(P<0.01或P<0.05);与基础值波幅相比,给药后波幅明显增高。结论戊巴比妥钠能够增大δ频段功率百分比,降低θ频段功率百分比。Objective To observe the effects of sodium pentobarbital on δ-band and θ-band of quantitative pharmaeo-electroencephalography（QPEEG） in rabbits. Methods QPEEG power spectral analysis was used to detect the changes of δ-、θ-band power in the percentage before and after intravenous injection of sodium pentobarbital 30 rng/kg in rabbits. Results Compared with the baseline,the percentage of δ-band power was significantly increased, but that of θ-band power was significantly decreased, at 30 s, 1,2,3,5 min and 10 min after administration（P〈0. 01 or P〈0. 05）. Compared with the baseline,the amplitude was significantly increased after administration. Conclusion Intravenous injection of sodium pentobarbital can increase the percentage of δ-band power and decrease the percentage of θ-band power in rabbits.

关 键 词：戊巴比妥钠 定量药物脑电图 功率谱分析 

分 类 号：R714[医药卫生—妇产科学]