肺弥散量测定在系统性红斑狼疮肺间质病变的意义  

Significance of interstitial lung disease in patients with systemic lupus erythematosus by the diffusing capacity of lung

作　　者：赖映君[1,2] 洪小平[1,2] 李莹[1,2] 陈春婵[1,2] 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院呼吸内科,广东深圳518020

出　　处：《中国医学工程》2012年第1期8-10,共3页China Medical Engineering

摘　　要：目的探讨肺弥散量(DLCO)测定对系统性红斑狼疮(SLE)肺间质性病变(ILD)的意义。方法对100例系统性红斑狼疮患者进行一氧化碳弥散量检测,并与X线胸片、肺部高分辨CT(HRCT)结果相比较;同时测定80例正常人的DLCO和X线胸片作为对照。结果 DLCO(以一氧化碳弥散吸收率<80%为标准)、X线胸片和肺部HRCT在SLE中检测到ILD的比率分别为45%、17%和35%。而正常人的一氧化碳弥散吸收率≥80%,X线胸片均正常。结论 DLCO和HRCT是检测SLE患者ILD的敏感方法,尤其是DLCO敏感性高、不受X线辐射、对ILD损害程度可进行量化、操作简单、费用低、易被患者接受等优点。因此DLCO测定可作为早期监测SLE患者ILD的指标。[ Objective ] To investigate significance of interstitial lung disease in patients with systemic lupus ery-thematosus by the diffusing Capacity of Carbon monoxide. [ Methods] 100 patients with systemic lupus erythematosus （SLE） were studied by diffusion Capacity of Carbon monoxide, chest radiography and HRCT. 80 healthy individuals were included as the control group. [ Results] 17 of the 100 （17%） patients with SLE were found to have ILD by chest radiography, HRCT abnormalities for ILD were noted in 35/100 （35%） of the patients with SLE ,Alterna- tion in DLCO was present in45 （45%） patients with SLE . The means of DLCO were （81 ＋ 18）% in SLE ,which were significantry different from that in the healthy controls [ DLCO = （ 102±9） % ] （ P 〈 0.01 ）. [ Conclusion] for the diagnosis of ILD in SLE , chest radiography was less sensitive than HRCT and DLCO , which is highly sensitive, without radioactivity and favorably accepted by patients , thus, could be the early indictor moniting of ILD patients with SLE.

关 键 词：系统性红斑狼疮 肺间质性病变 肺弥散量 

分 类 号：R593.241[医药卫生—内科学]