前列地尔脂微球载体注射液治疗冠心病并闭塞性周围动脉粥样硬化的疗效  

Therapeutic effects of Lipo-prostaglandin E1 injection on coronary heart disease complicated peripheral arteriosclerosis obliteration

作　　者：刘倩倩[1] 査滨 温亮[1] 杨庆辉[1] 陈延军[1] 

机构地区：[1]哈尔滨医科大学附属第四医院心内科,黑龙江哈尔滨150001 [2]哈尔滨市二四二医院社区病房

出　　处：《心血管康复医学杂志》2012年第2期168-172,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察静脉注射前列地尔脂微球载体(Lipo-PGE1)注射液治疗冠心病合并闭塞性周围动脉粥样硬化(PAO)的有效性和安全性。方法:入选49例冠心病合并PAO患者,分为常规治疗组(22例)和前列地尔治疗组(27例,在常规治疗基础上给予Lipo-PGE110μg/d,静脉注射,连用14d)。分别于治疗开始及14d时进行6min步行距离试验(6MWT)、Bruce运动平板试验[测代谢当量(MET)]、超声心动图、踝/肱指数(ABI)及血清标记物检查。结果:与常规治疗组治疗后比较,前列地尔组6MWT[(324.8±65.5)m比(358.2±76.7)m]、METs[(3.5±0.9)比(4.3±1.3)]、ABI[(0.901±0.02)比(1.079±0.05)]明显增加,同型半胱氨酸(Hcy)水平[(16.8±1.91)μmol/L比(10.7±0.55)μmol/L]明显下降,P均<0.05。无患者因严重不良反应退出研究。结论:常规治疗联合应用前列地尔脂微球载体注射液,可改善冠心病合并闭塞性周围动脉粥样硬化患者的踝/肱指数和运动耐量,降低同型半胱氨酸水平并且安全性和耐受性良好。Objective： To investigate efficacy and safety of intravenous injection of Lipo-prostaglandin E1（Lipo-PGE1）treating coronary heart disease（CHD） complicated peripheral arteriosclerosis obliteration（PAO）.Methods：A total of 49 CHD patients with PAO were divided into routine treatment group（n=22） and Lipo-PGE1 group（received Lipo-PGE1 intravenous injection 10 μg/d based on routine treatment for 14d）.At the beginning and 14d after treatment,all patients underwent 6-min walking test（6MWT）,Bruce treadmill exercise test for examining METs,echocardiography and ankle/brachial index（ABI） etc were measured.Results：Compared with routine treatment group after treatment,there were significant increase in 6MWT [（324.8±65.5） m vs.（358.2±76.7） m],METs [（3.5±0.9） vs.（4.3±1.3）]and ABI [（0.901±0.02） vs.（1.079±0.05）],and significant decrease in homocystine（Hcy）level [（16.8±1.91） μmol/L vs.（10.7±0.55） μmol/L]in Lipo-PGE1 group,P0.05 all.No patients exited because of severe adverse reactions.Conclusions：Lipo-PGE1 intravenous injection based on routine treatment can improve ankle/brachial index,exercise tolerance and Hcy levels in CHD patients complicated peripheral arteriosclerosis obliteration,and it possesses good tolerance and safety.

关 键 词：冠状动脉疾病 动脉硬化 闭塞性 前列地尔 

分 类 号：R543.5[医药卫生—心血管疾病]