石英晶体微天平在手性识别中的应用  

Progress of Quartz Crystal Microbalance in Chiral Recognition

作　　者：邓小娟[1,2] 丁国生[2] 林奎[1,2] 姚琲[1,2] 

机构地区：[1]天津大学材料科学与工程学院,天津300072 [2]天津大学分析测试中心,天津300072

出　　处：《分析测试学报》2012年第4期502-508,共7页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(21005054);天津大学自主创新基金资助项目(130-60302010)

摘　　要：石英晶体微天平(QCM)是一类重要的质量型检测器,因具有灵敏度高、分析速度快、检测成本低等优点而具有极好的应用前景,现已广泛应用于环境监测、药物分析、食品质量控制等诸多领域。手性工程的崛起对简单、快速、在线的手性检测技术提出了挑战,QCM手性传感器就是其中一个重要的发展分支。该文简要介绍了QCM的典型实验装置和基本传感原理,详细综述了近年来QCM在手性识别领域的研究进展,包括以环糊精衍生物、分子印迹聚合物、氨基酸衍生物等为手性主体的QCM在手性识别中的应用,并对其今后的发展进行了展望。Quartz crystal microbalance（QCM） is one of the mass-sensitive detectors.It is widely used in many fields such as environmental monitoring,pharmaceutical analysis,food quality control,etc,due to its high sensitivity,fast response and low cost.The development of chiral engineering requires chiral analytical technology with simple handling,high speed and on-line operation.QCM chiral sensor represents one of the most important branches of future research.In this review,the typical experimental apparatus and the basic principle of QCM are introduced in brief,then the recent coating materials used for QCM in chiral recognition are reviewed in detail,which include cyclodextrin derivatives,molecular imprinting polymers,amino acid derivatives,etc.The prospects of this field are also put forward.

关 键 词：石英晶体微天平(QCM) 手性识别 综述 

分 类 号：TP212.9[自动化与计算机技术—检测技术与自动化装置] G353.11[自动化与计算机技术—控制科学与工程]