复方红景天制剂提高小鼠运动耐力的实验研究  

The effect of Rhodiola Compound on improving exercise tolerance in mice

作　　者：徐荣[1] 葛华[2] 王永新[2] 

机构地区：[1]空军总医院药学部,北京100142 [2]空军航空医学研究所,北京100142

出　　处：《中国药物应用与监测》2012年第2期78-80,共3页Chinese Journal of Drug Application and Monitoring

基　　金：国家科技重大专项(2008ZXJ09004-034;2010ZX09102-204);国家自然科学基金项目(81072914;81073083)

摘　　要：目的:研究复方红景天制剂对小鼠的抗疲劳作用。方法:将SPF级昆明种小鼠随机分成复方红景天制剂低、中、高剂量组和阴性对照组。每日灌胃1次,连续30 d后,分别测定小鼠负重游泳时间、血清尿素、肝糖原和血乳酸的含量。结果:与阴性对照组相比,复方红景天制剂可以延长小鼠负重游泳时间(P<0.05),明显增加肝糖原含量(P<0.01),显著降低运动小鼠的血乳酸含量(P<0.01)。各剂量组小鼠血清尿素浓度无显著性差异(P>0.05)。结论:复方红景天制剂具有抗疲劳作用。Objective： To study the anti-fatigue function of Rhodiola Compound in mice. Methods： Kuming mice （SPF） were randomly divided into low-dose, medium-dose, high-dose group of Rhodiola Compound and negative control group. Mice were administered once daily for 30 days. The loaded-swimming time, serum urea, hepatic glycogen and lactic acid level in blood were measured. Results： Compared with negative control group, the time of loading swimming （P 〈 0.05） and the content of hepatic glycogen （P 〈 0.01） were significantly increased in Rhodiola Compound group. The lactic acid level in blood was significantly reduced in Rhodiola Compound group （P 〈 0.01）. There was no significant difference in concentration of serum urea among the groups （P 〉 0.05）. Conclusion： Rhodiola Compound could alleviate physical fatigue in mice.

关 键 词：复方红景天制剂 抗疲劳 动物实验 

分 类 号：R285[医药卫生—中药学]